ArticleHuman genomics2004
Distribution of genome-wide linkage disequilibrium based on microsatellite loci in the Samoan population.
Article in Human genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A stop-gain variant inHGG advances · 2023Pooled it
- The Soifua Manuia reference panel with 2,570 Samoan haplotypes improves genotype imputation quality among Samoans.Communications biology · 2026Article
- A thrifty variant in CREBRF strongly influences body mass index in Samoans.Nature genetics · 2016Article
- Dietary habits of Samoan adults in an urban Australian setting: a cross-sectional study.Public health nutrition · 2016Article
- INSIG2 variants, dietary patterns and metabolic risk in Samoa.European journal of clinical nutrition · 2013Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.Annals of human genetics · 2012Article
- Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders.Epigenetics · 2011Article
- A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.BMC medical genetics · 2009Article
- Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.BMC medical genetics · 2009Article
- Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa.Obesity (Silver Spring, Md.) · 2009Article
- Linkage mapping of CVD risk traits in the isolated Norfolk Island population.Human genetics · 2008Article
- A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans.Annals of human genetics · 2008Article
- A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands.Journal of lipid research · 2008Article
- Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.Human biology · 2008Article
- Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation.Human genetics · 2007Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Whole genome-wide scanning for susceptibility loci based on linkage disequilibrium (LD) has been proposed as a powerful strategy for mapping common complex diseases, especially in isolated populations. We recruited 389 individuals from 175 families in the US territory of American Samoa, and 96 unrelated individuals from American Samoa and the independent country of Samoa in order to examine background LD by using a 10 centimorgan (cM) map containing 381 autosomal and 18 X-linked microsatellite markers. We tested the relationship between LD and recombination fraction by fitting a regression model. We estimated a slope of -0.021 (SE 0.00354; p<0.0001). Based on our results, LD in the Samoan population decays steadily as the recombination fraction between autosomal markers increases. The patterns of LD observed in the Samoan population are quite similar to those previously observed in Palau but markedly contrast with those observed in a non-isolated Caucasian sample, where there is essentially no marker-to-marker LD. Our analyses support the hypothesis of a recent bottleneck, which is consistent with the known demographic history of the Samoan population. Furthermore, population substructure tests support the hypothesis that self-identified Samoans represent one homogenous genetic population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.