ArticleHuman genomics2004
Genome-wide analysis of the human Alu Yb-lineage.
Article in Human genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- Review
- A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A comprehensive analysis of chimpanzee (Pan Troglodytes)-specific AluYb8 element.Genes & genomics · 2020Article
- Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury.Heliyon · 2017Article
- Discovery of rare, diagnosticMobile DNA · 2017Article
- Article
- Assembly and diploid architecture of an individual human genome via single-molecule technologies.Nature methods · 2015Article
- Article
- BLAT-based comparative analysis for transposable elements: BLATCAT.BioMed research international · 2014Article
- Analysis of western lowland gorilla (Gorilla gorilla gorilla) specific Alu repeats.Mobile DNA · 2013Article
- Identification of three new Alu Yb subfamilies by source tracking of recently integrated Alu Yb elements.Mobile DNA · 2013Article
- Article
- Transposable Elements: No More 'Junk DNA'.Genomics & informatics · 2012Article
- tRNA genes protect a reporter gene from epigenetic silencing in mouse cells.Cell cycle (Georgetown, Tex.) · 2011Article
- Reading TE leaves: new approaches to the identification of transposable element insertions.Genome research · 2011Article
- A new set of markers for human identification based on 32 polymorphic Alu insertions.European journal of human genetics : EJHG · 2010Article
- Laboratory methods for the analysis of primate mobile elements.Methods in molecular biology (Clifton, N.J.) · 2010Article
- Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements.Gene · 2009Article
- Alu-directed transcriptional regulation of some novel miRNAs.BMC genomics · 2009Article
- The impact of retrotransposons on human genome evolution.Nature reviews. Genetics · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The Alu Yb-lineage is a 'young' primarily human-specific group of short interspersed element (SINE) subfamilies that have integrated throughout the human genome. In this study, we have computationally screened the draft sequence of the human genome for Alu Yb-lineage subfamily members present on autosomal chromosomes. A total of 1,733 Yb Alu subfamily members have integrated into human autosomes. The average ages of Yb-lineage subfamilies, Yb7, Yb8 and Yb9, are estimated as 4.81, 2.39 and 2.32 million years, respectively. In order to determine the contribution of the Alu Yb-lineage to human genomic diversity, 1,202 loci were analysed using polymerase chain reaction (PCR)-based assays, which amplify the genomic regions containing individual Yb-lineage subfamily members. Approximately 20 percent of the Yb-lineage Alu elements are polymorphic for insertion presence/absence in the human genome. Fewer than 0.5 percent of the Yb loci also demonstrate insertions at orthologous positions in non-human primate genomes. Genomic sequencing of these unusual loci demonstrates that each of the orthologous loci from non-human primate genomes contains older Y, Sg and Sx Alu family members that have been altered, through various mechanisms, into Yb8 sequences. These data suggest that Alu Yb-lineage subfamily members are largely restricted to the human genome. The high copy number, level of insertion polymorphism and estimated age indicate that members of the Alu Yb elements will be useful in a wide range of genetic analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.