ArticleLipids2004
The age-related decline in intestinal lipid uptake is associated with a reduced abundance of fatty acid-binding protein.
Article in Lipids, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Plasma lipidome variation during the second half of the human lifespan is associated with age and sex but minimally with BMI.PloS one · 2019Trial
- A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement.Life medicine · 2024Article
- The Roles of Lipid Metabolism in the Pathogenesis of Chronic Diseases in the Elderly.Nutrients · 2023Review
- Effect of Clinical and Laboratory Parameters on HDL Particle Composition.International journal of molecular sciences · 2023Article
- Lipid and glucose metabolism in senescence.Frontiers in nutrition · 2023Review
- A gut-centric view of aging: Do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence?Aging cell · 2022Review
- Review
- Review
- Quantitative proteomics to study aging in rabbit liver.Mechanisms of ageing and development · 2020Article
- Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production.BMC genomics · 2019Article
- Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging.Molecular and cellular endocrinology · 2017Review
- Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys.Lipids in health and disease · 2016Article
- Computationally Modeling Lipid Metabolism and Aging: A Mini-review.Computational and structural biotechnology journal · 2015Review
- Analysis of stress-responsive transcriptome in the intestine of Asian seabass (Lates calcarifer) using RNA-seq.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass.BMC genomics · 2013Article
- Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?Pharmaceutical research · 2011Article
- Decreased expression of Intestinal I- and L-FABP levels in rare human genetic lipid malabsorption syndromes.Histochemistry and cell biology · 2007Article
- Aging and the intestine.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with changes in the absorptive capacity of the small intestine. We tested the hypotheses that (i) aging is associated with a decline in lipid absorption, and that (ii) this decreased lipid absorption is due to a decline in the abundance of mRNA and/or the enterocyte cytosolic intestinal FA-binding protein (I-FABP), the liver FA-binding protein (L-FABP), and the ileal lipid-binding protein (ILBP). In vitro uptake studies were performed on Fischer 344 rats at ages 1, 9, and 24 mon. Northern blotting (L-FABP, ILBP) and immunohistochemistry (I-FABP, ILBP) were performed. Aging was associated with decreased animal weights, but the surface area of the intestine was not significantly altered with age. The rates of ileal uptake of 16:0, 18:0, 18:1, and 18:2 were reduced by greater than 50% with aging when expressed on the basis of mucosal weight. This decline was not associated with reduced expression of mRNA for L-FABP or ILBP but was associated with a 50% decrease in the abundance of I-FABP and a 40% decrease in the abundance of ILBP. Thus, the decrease with aging in the ileal uptake of some FA when rates were expressed on the basis of mucosal weight was associated with a reduced abundance of I-FABP and ILBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.