ArticleAmerican journal of human genetics2005
A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- The Dawn and Advancement of the Knowledge of the Genetics of Migraine.Journal of clinical medicine · 2024Review
- Molecular and Cellular Neurobiology of Circadian and Circannual Rhythms in Migraine: A Narrative Review.International journal of molecular sciences · 2023Review
- Role of Omics in Migraine Research and Management: A Narrative Review.Molecular neurobiology · 2022Review
- Continuous and intermittent theta burst stimulation to the visual cortex do not alter GABA and glutamate concentrations measured by magnetic resonance spectroscopy.Brain and behavior · 2022Article
- A review of migraine genetics: gathering genomic and transcriptomic factors.Human genetics · 2022Review
- RAR-related orphan receptor A: One gene with multiple functions related to migraine.CNS neuroscience & therapeutics · 2020Article
- Assessing differential effects of single and accelerated low-frequency rTMS to the visual cortex on GABA and glutamate concentrations.Brain and behavior · 2020Article
- Exploring Neuronal Vulnerability to Head Trauma Using a Whole Exome Approach.Journal of neurotrauma · 2020Article
- Epilepsy and migraine-Are they comorbidity?Genes & diseases · 2018Review
- Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Family studies to find rare high risk variants in migraine.The journal of headache and pain · 2017Review
- Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.Alcoholism, clinical and experimental research · 2017Review
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Headache and epilepsy.Current pain and headache reports · 2013Review
- Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.PloS one · 2013Article
- Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.Gene · 2012Article
- Genetics of migraine in the age of genome-wide association studies.The journal of headache and pain · 2012Review
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is the most common type of chronic episodic headache. Several population-based family studies have suggested a strong genetic predisposition to migraine, especially migraine with aura (MA). Although several susceptibility loci have been identified, none of the numerous studies performed to date have led to the identification of a gene responsible for the more common forms of migraine. GABA-A receptors and their modulator sites seem to be involved in the pathophysiological events that underlie migraine. We report on clinical and molecular data from a total of 10 families with MA, in which MA segregates as an autosomal dominant trait and presents with homogeneous clinical features. After excluding linkage with the known candidate loci, we used a functional candidate approach and genotyped these families with markers from the 15q11-q13 genomic region, which contains the genes encoding GABA-A receptor subunits. Evidence of linkage was obtained with a parametric two-point linkage analysis (maximum LOD score of 5.56 at a recombination fraction of 0.001 for marker GABRB3) and was supported by multipoint analysis (maximum LOD score of 6.54 between markers D15S113 and D15S1019). The critical region spanned 3.6 Mb. These results provide the basis for further investigation of the hypothesized relationship between a GABA-A receptor dysfunction and migraine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.