ArticlePediatric research2005
Developmental changes in proximal tubule tight junction proteins.
Article in Pediatric research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026Review
- Potassium regulation in the neonate.Pediatric nephrology (Berlin, Germany) · 2017Article
- Tight junctions of the proximal tubule and their channel proteins.Pflugers Archiv : European journal of physiology · 2017Review
- Minireview: Steroid/nuclear receptor-regulated dynamics of occluding and anchoring junctions.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Age-related changes of claudin expression in mouse liver, kidney, and pancreas.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Expression of claudin-7 in benign kidney and kidney tumors.International journal of clinical and experimental pathology · 2008Article
- Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.American journal of physiology. Renal physiology · 2006Article
- Maturation of rat proximal tubule chloride permeability.American journal of physiology. Regulatory, integrative and comparative physiology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We demonstrated previously that neonatal proximal tubules have a lower passive paracellular permeability to chloride ions and higher resistance than that of adult proximal tubules. In addition, administration of thyroid hormone to neonates, before the normal maturational increase in serum thyroid hormone levels, prematurely accelerates the developmental increase in chloride permeability to adult levels. To test the hypothesis that there is a maturational change in tight junction proteins and that thyroid hormone mediates these changes, we examined the two known tight junction proteins present in proximal tubules, occludin and claudin 2. Using immunoblot and immunohistochemistry, we demonstrated that claudin 2 has a 4-fold greater abundance in neonatal proximal tubules than in adult tubules. Occludin, however, has a 4-fold greater expression in adult tubules than in neonatal tubules. Administration of thyroid hormone to neonates did not affect claudin 2 expression, occludin expression, or the transepithelial resistance in rat proximal tubule cells in vitro. In conclusion, there are postnatal maturational changes in tight junction proteins. The factors that cause these maturational changes are unknown but unlikely to be due solely to the maturational increase in thyroid hormone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.