ReviewCNS drugs2004
Obsessive-compulsive disorder in schizophrenia: clinical characteristics and treatment.
Review in CNS drugs, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association.Schizophrenia bulletin · 2011Pooled it
- Modeling the Determinants of Subjective Well-Being in Schizophrenia.Schizophrenia bulletin · 2025Trial
- Sex-specific diagnostic trajectories and time to transition from non-SMI to severe mental illness in Chinese adolescent inpatients.Frontiers in psychiatry · 2026Article
- Prevalence of obsessive-compulsive symptoms in patients with schizophrenia treated with clozapine: a scoping review.BMC psychiatry · 2025Article
- Disruption of consciousness depends on insight in obsessive-compulsive disorder and on positive symptoms in schizophrenia.Neuroscience of consciousness · 2025Article
- Untangling Depression in Schizophrenia: The Role of Disorganized and Obsessive-Compulsive Symptoms and the Duration of Untreated Psychosis.Biomedicines · 2024Article
- The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study.The British journal of psychiatry : the journal of mental science · 2024Observational
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- Association between obsessive-compulsive disorder and the risk of schizophrenia using the Korean National Health Insurance Service-National Sample Cohort: a retrospective cohort study.Epidemiology and psychiatric sciences · 2023Article
- Disclosing common biological signatures and predicting new therapeutic targets in schizophrenia and obsessive-compulsive disorder by integrated bioinformatics analysis.BMC psychiatry · 2023Article
- Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder.Psychiatry research · 2021Article
- Integration of Clozapine-associated Harm Obsessions into Cognitive Behavioral Conceptualization and Treatment Planning for Thought Broadcasting: A Case Study.Journal of psychiatric practice · 2020Article
- The Relationships Between Obsessive-Compulsive Disorder and Psychosis: An Unresolved Issue.Clinical neuropsychiatry · 2020Article
- Clozapine generates obsessive compulsive disorder-like behavior in mice.Molecular brain · 2020Article
- Discerning undifferentiated anxiety from syndromal anxiety in acute-phase schizophrenia.Annals of general psychiatry · 2020Article
- Obsessive-Compulsive Symptoms in Schizophrenia: an Up-To-Date Review of Literature.Current psychiatry reports · 2019Review
- Obsessive-compulsive disorder comorbid with schizophrenia and bipolar disorder.Indian journal of psychiatry · 2019Review
- Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia.Psychological medicine · 2018Article
- Cognitive-behavioural therapy for obsessive-compulsive disorder co-occurring with psychosis: Systematic review of evidence.World journal of psychiatry · 2016Article
- Increased orbitofrontal cortex activation associated with "pro-obsessive" antipsychotic treatment in patients with schizophrenia.Journal of psychiatry & neuroscience : JPN · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a considerable overlap of schizophrenia and obsessive-compulsive disorder (OCD) in the structural and functional brain abnormalities involved, role of the dopamine/serotonin neurotransmitter systems, and some demographic and clinical characteristics. Although OCD co-occurs in a substantial proportion of schizophrenia patients, a systematic evaluation of the clinical features and treatment of this population is lacking. This review critically evaluates findings of recent studies pertaining to the rate of occurrence of OCD or obsessive-compulsive symptoms (OCS) in schizophrenia and the clinical characterisation of the schizo-obsessive subtype. Specifically, interrelationships between obsessive-compulsive and schizophrenic symptoms in terms of temporal relationships and their association with specific schizophrenia subtypes and the effect of OCS on the severity of schizophrenia symptoms are addressed. In the absence of evidence-based data, tentative therapeutic approaches in this difficult-to-treat patient subgroup are suggested. These include monotherapy with atypical antipsychotic agents or a combination of either typical or atypical antipsychotics with SSRIs or clomipramine. The clinical characteristics of antipsychotic-induced OCS/OCD are also presented to facilitate identification and management of this rare but clinically significant adverse effect. Finally, future directions of research in schizophrenia-OCD comorbidity relevant to clinical practice are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.