ReviewVirchows Archiv : an international journal of pathology2005
Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia.
Review in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Diagnostic potential of total serum ghrelin in autoimmune gastritis: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Pancreatic acinar cells--a normal finding at the gastroesophageal junction? Data from a prospective Central European multicenter study.Virchows Archiv : an international journal of pathology · 2013Trial
- Clinical Heterogeneity of Early-Onset Autoimmune Gastritis: From the Evidence to a Pediatric Tailored Algorithm.Diseases (Basel, Switzerland) · 2025Article
- Improving the Diagnosis of Autoimmune Gastritis: From Parietal Cell Antibodies to H+/K+ ATPase Antibodies.Diagnostics (Basel, Switzerland) · 2024Review
- Chronic Autoimmune Gastritis: Modern Diagnostic Principles.Diagnostics (Basel, Switzerland) · 2021Review
- CagA increases DNA methylation and decreases PTEN expression in human gastric cancer.Molecular medicine reports · 2019Article
- Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study.World journal of gastroenterology · 2018Article
- Autoimmunity and Gastric Cancer.International journal of molecular sciences · 2018Review
- Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review.World journal of gastroenterology · 2017Review
- Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis.BioMed research international · 2015Review
- Autoimmune gastritis presenting as iron deficiency anemia in childhood.World journal of gastroenterology · 2014Observational
- Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer.Digestive diseases and sciences · 2012Article
- Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach.World journal of gastrointestinal pathophysiology · 2011Article
- Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.The American journal of pathology · 2011Article
- Development of corpus atrophic gastritis may be associated with Helicobacter pylori-related idiopathic thrombocytopenic purpura.Journal of gastroenterology · 2011Article
- Gastric epithelial stem cells.Gastroenterology · 2011Review
- The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.Developmental biology · 2009Article
- Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability.European journal of pediatrics · 2008Article
- Mucosal colonization of gastric endocrine tumors mimicking mixed neoplasms.Virchows Archiv : an international journal of pathology · 2008Article
- Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils.Cancer science · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic gastritis with gastric mucosa atrophy, intestinal metaplasia and endocrine cell hyperplasia are alterations with an increased risk for the development of gastric neoplasias. Immunological studies in autoimmune gastritis, in atrophic Helicobacter pylori gastritis and in studies with transgenic mice point to a central role of the parietal cell in the development of gastric mucosa atrophy. Destruction of gastric epithelial cells alone might not be sufficient for the loss of complete gastric glands. Gastric atrophy, endocrine cell hyperplasia and intestinal and pancreatic metaplasia can be regarded as the result of altered morphogenesis within the gastric mucosa. Impaired expression of the gastric morphogenic factor Sonic Hedgehog by parietal cells and increased expression of the transcriptional activators of intestinal and pancreatic differentiation, namely CDX2 and PDX1, seem to be crucial for the development of gastric atrophy and for intestinal, endocrine and pancreatic transdifferentiation processes. Altered expression of these morphogenic factors is partly caused by changes in the gastric milieu. Further studies concerning the normal and pathological morphogenesis of the gastric mucosa and related tissues might give new insight into the pathogenesis of gastric atrophy and metaplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.