Evidence map›Paper›PMID 15583347›Full record

ArticleJournal of clinical microbiology2004

Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection.

Preeti Pancholi, Steven Park, David Perlin, Christine Kubin, Phyllis Della-Latta

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Preeti PancholiClinical Microbiology Laboratory, Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, 622 West 168th St., CHS 3-326, New York, NY 10032, USA. prp9005@nyp.org
Steven Park
David Perlin
Christine Kubin
Phyllis Della-Latta
International Center for Public Health · USNewYork–Presbyterian Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocular yeast infections in diabetics are a therapeutic challenge. Drug resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.

Indexed as

Antifungal AgentsCandida albicansCandidiasisDrug Resistance, FungalEye Infections, FungalFemaleFluconazoleFungal ProteinsHumansMembrane Transport ProteinsMicrobial Sensitivity TestsMiddle AgedRNA, MessengerUp-RegulationAntifungal AgentsCDR1 protein, Candida albicansFluconazoleFungal ProteinsMembrane Transport ProteinsRNA, Messenger

Identifiers

PMID15583347
PMCPMC535233
OpenAlexW2073408948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.