ArticleJournal of clinical microbiology2004
Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serotype distribution of invasive and non-invasive pneumococcal disease in children ≤5 years of age following the introduction of 10- and 13-valent pneumococcal conjugate vaccines in infant national immunization programs: a systematic literature review.Frontiers in public health · 2025Pooled it
- Fourier-transform infrared spectroscopy for rapidFrontiers in microbiology · 2025Article
- Emerging vaccine strategies against the incessant pneumococcal disease.NPJ vaccines · 2023Review
- The Pneumococcal Divisome: Dynamic Control ofFrontiers in microbiology · 2021Review
- Emergence of Multidrug-Resistant Pneumococcal Serotype 35B among Children in the United States.Journal of clinical microbiology · 2017Article
- Serotypes and Clonal Diversity of Streptococcus pneumoniae Causing Invasive Disease in the Era of PCV13 in Catalonia, Spain.PloS one · 2016Article
- Molecular Characterization of the Recently Emerged Poultry Pathogen Ornithobacterium rhinotracheale by Multilocus Sequence Typing.PloS one · 2016Article
- Nasopharyngeal Bacterial Carriage in the Conjugate Vaccine Era with a Focus on Pneumococci.Journal of immunology research · 2015Review
- Pneumococcal capsular switching: a historical perspective.The Journal of infectious diseases · 2013Article
- Article
- Multiple-locus variable-number tandem-repeat analysis of Streptococcus pneumoniae and comparison with multiple loci sequence typing.BMC microbiology · 2012Article
- Article
- Sequence diversity within the capsular genes of Streptococcus pneumoniae serogroup 6 and 19.PloS one · 2011Article
- The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes.FEMS immunology and medical microbiology · 2010Review
- Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa.Journal of clinical microbiology · 2009Article
- Impact of capsular switch on invasive pneumococcal disease incidence in a vaccinated population.PloS one · 2008Article
- Genetic diversity among Enterococcus faecalis.PloS one · 2007Article
- Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland.Antimicrobial agents and chemotherapy · 2007Article
- Comparison of multilocus sequence typing, pulsed-field gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates.Journal of clinical microbiology · 2006Article
- Variation in the presence of neuraminidase genes among Streptococcus pneumoniae isolates with identical sequence types.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We have used multilocus sequence typing (MLST) and serotyping to build a phylogenetic framework for pneumococcal disease isolates in Scotland that provides a snapshot of the relationships between capsular type and genotype. The results show that while the MLST type correlates with the serotype, isolates within a serotype can belong to a number of individual clonal complexes or sequence types (STs). We also show that isolates of the same ST can express different capsular polysaccharides, i.e., display capsular switching, and that this phenomenon is observed both for capsular types commonly isolated from patients with invasive disease and for serogroups less commonly isolated from patients with invasive disease but which may commonly be carried asymptomatically in the human nasopharynx.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.