ArticleJournal of clinical microbiology2004
Antigenic divergence suggested by correlation between antigenic variation and pulsed-field gel electrophoresis profiles of Bordetella pertussis isolates in Japan.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines.Microbial genomics · 2018Article
- Genetic Variation of Bordetella pertussis in Austria.PloS one · 2015Article
- Perplexities of pertussis: recent global epidemiological trends and their potential causes.Epidemiology and infection · 2014Review
- Population diversity among Bordetella pertussis isolates, United States, 1935-2009.Emerging infectious diseases · 2012Article
- Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan.PloS one · 2012Article
- Multilocus Sequence Analysis of Housekeeping Genes and Antigenic Determinant Genes in Bordetella pertussis Strains Isolated in Korea.Osong public health and research perspectives · 2011Article
- Studies on Prn variation in the mouse model and comparison with epidemiological data.PloS one · 2011Article
- Differential expression of type III effector BteA protein due to IS481 insertion in Bordetella pertussis.PloS one · 2011Article
- Article
- Effect of vaccination on Bordetella pertussis strains, China.Emerging infectious diseases · 2010Article
- Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis.Emerging infectious diseases · 2010Article
- Bordetella pertussis strains circulating in Europe in 1999 to 2004 as determined by pulsed-field gel electrophoresis.Journal of clinical microbiology · 2007Article
- Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999-2003.BMC infectious diseases · 2006Article
- Antigenic divergence of Bordetella pertussis isolates in Taiwan.Journal of clinical microbiology · 2005Article
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5 authors.
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Abstract
Antigenic divergence has been found between Bordetella pertussis vaccine strains and circulating strains in several countries. In the present study, we analyzed B. pertussis isolates collected in Japan from 1988 to 2001 using pulsed-field gel electrophoresis (PFGE) and sequencing of two virulence-associated proteins. The 107 isolates were classified into three major groups by PFGE analysis; 87 (81%) were type A, 19 (18%) were type B, and 1 (1%) was type C. Sequence analysis of the S1 subunit of pertussis toxin (ptxS1) and adhesion pertactin (prn) genes revealed the presence of two (ptxS1A and ptxS1B) and three (prn1, prn2, and prn3) variants, respectively, in the isolates. Among those isolates, 82 (95%) of the 87 type A strains and the type C strain had the same combination of ptxS1B and prn1 alleles (ptxS1B/prn1) as the Japanese vaccine strain. On the other hand, 17 (90%) of 19 type B strains had an allele (ptxS1A/prn2) distinct from that of the vaccine strain. A correlation was found between the antigenic variation and the PFGE profile in the isolates. In addition, the frequency of the type B strain was 0, 27, 0, 42, and 37% of the isolates in the periods 1988 to 1993, 1994 to 1995, 1996 to 1997, 1998 to 1999, and 2000 to 2001, respectively. In contrast, the number of reported pertussis-like and pertussis cases decreased gradually from 1991 on, suggesting that the antigenic divergence did not affect the efficacy of pertussis vaccination in Japan.
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