ArticleExperimental brain research2005
Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices.
Article in Experimental brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces.Scientific reports · 2017Article
- Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism.Experimental and therapeutic medicine · 2015Article
- Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation.Psychopharmacology · 2015Article
- NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Article
- Growth hormone and cognitive function.Nature reviews. Endocrinology · 2013Review
- Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling.PloS one · 2013Article
- Bi-directional regulation of CaMKIIα phosphorylation at Thr286 by NMDA receptors in cultured cortical neurons.Journal of neurochemistry · 2012Article
- Activation of NR2A receptors induces ischemic tolerance through CREB signaling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis.Progress in neuro-psychopharmacology & biological psychiatry · 2009Review
- Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
- Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity.BMC neuroscience · 2007Article
- What are the mechanisms underlying the involvement of different subtypes of NMDA receptors in inducing long-term potentiation and depression in the hippocampus?Neuroscience and behavioral physiology · 2007Review
- Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex.Molecular pain · 2007Article
- NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate receptors responding to N-methyl-D: -aspartate (NMDA) are involved in neural development, excitotoxicity and neuronal plasticity. Each receptor includes at least two NR2 subunits. Here, we have examined the effects of selective antagonists of NR2A and NR2B subunits (NVP-AAM07 and Ro25-6981 respectively) on the effects of NMDA in the CA1 field of rat hippocampal slices. We have observed that Ro25-6981 potentiates, rather than blocks, the effects of NMD on field EPSPs and paired-pulse interactions (indicators of presynaptic effects) and on postsynaptic depolarisation in hippocampal slices. The NR2A subunit antagonist NVP-AAM077 blocks the effects of NMDA alone, or after potentiation by Ro25-6981. The potentiation of NMDA by Ro25-6981 was not prevented by staurosporine (protein kinase inhibitor), okadaic acid (an inhibitor of serine/threonine protein phosphatases) or anisomycin (protein synthesis inhibitor), but was prevented by cyclosporin A, which inhibits Ca2+/calmodulin-dependent phosphatase 2B [calcineurin]. NMDA-dependent long-term potentiation (LTP) induced by electrical stimulation was not prevented by Ro25-6981 but was prevented by selective blockade of the NR2A subunit. The results suggest that, at both presynaptic and postsynaptic sites in the rat hippocampus, NR2B-subunit-containing receptors limit NMDA receptor function by inhibitory restraint over NR2A-subunit-containing receptors, via calcineurin activation, and that LTP induction critically involves primarily receptors containing the NR2A subunit. Endogenous factors or drugs that modify this NR2B/NR2A interaction could have a major influence on synaptic transmission and plasticity in the brain.
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