ArticleOncogene2005
Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Original Research: miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.Oncotarget · 2016Article
- Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma.Journal of translational medicine · 2014Article
- The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage.Oncogenesis · 2012Article
- Molecular genetics of ependymoma.Chinese journal of cancer · 2011Review
- Loss of heterozygosity analysis of microsatellites on multiple chromosome regions in dysplasia and squamous cell carcinoma of the esophagus.Experimental and therapeutic medicine · 2011Article
- Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis.British journal of cancer · 2011Article
- MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma.BMC cancer · 2011Article
- Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Microsatellite analysis in multistage carcinogenesis of esophageal squamous cell carcinoma from Chongqing in Southern China.International journal of molecular sciences · 2011Article
- KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma.The American journal of pathology · 2011Article
- A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck.Carcinogenesis · 2010Article
- Decreased expression of FBXW7 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.Experimental and therapeutic medicine · 2010Article
- Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes.Blood · 2009Review
- Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.Oncogene · 2008Article
- Article
- The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.Chromosoma · 2005Review
- Genome-wide profiling of lncRNAs in pediatric intracranial ependymomas identifiesNeuro-oncology advancesArticle
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The key genes involved in the development of esophageal squamous cell carcinoma (ESCC) remain to be elucidated. Previous studies indicate extensive genomic alterations occur on chromosome 9 in ESCC. Using a monochromosome transfer approach, this study provides functional evidence and narrows down the critical region (CR) responsible for chromosome 9 tumor suppressing activity to a 2.4 Mb region mapping to 9q33-q34 between markers D9S1798 and D9S61. Interestingly, a high prevalence of allelic loss in this CR is also observed in primary ESCC tumors by microsatellite typing. Allelic loss is found in 30/34 (88%) tumors and the loss of heterozygosity (LOH) frequency ranges from 67 to 86%. Absent to low expression of a 9q32 candidate tumor suppressor gene (TSG), DEC1 (deleted in esophageal cancer 1), is detected in four Asian ESCC cell lines. Stably expressing DEC1 transfectants provide functional evidence for inhibition of tumor growth in nude mice and DEC1 expression is decreased in tumor segregants arising after long-term selection in vivo. There is 74% LOH in the DEC1 region of ESCC primary tumors. This study provides the first functional evidence for the presence of critical tumor suppressive regions on 9q33-q34. DEC1 is a candidate TSG that may be involved in ESCC development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.