ArticleGenetics2004
Genomic deletions of the Drosophila melanogaster Hsp70 genes.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 114 citations in OpenAlex.
- Characterization of Heat Shock Protein Expression and Its Application to Temporal Gene Expression in the Nematode Pristionchus pacificus.Development, growth & differentiation · 2026Article
- Arc controls organ architecture through modulation of Crb and MyoII.The Journal of cell biology · 2025Article
- Fruit flies exploit behavioral fever as a defense strategy against parasitic insects.Science advances · 2025Article
- CRISPR/Cas9-mediated tissue-specific knockout and cDNA rescue using sgRNAs that target exon-intron junctions inSTAR protocols · 2022Article
- The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour inFrontiers in aging · 2022Article
- Heat shock proteins: a history of study in Russia.Cell stress & chaperones · 2021Review
- Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster.Cell stress & chaperones · 2021Article
- Expression of Heat Shock Protein 70 Is Insufficient To ExtendG3 (Bethesda, Md.) · 2019Article
- The Hsp70 chaperone is a major player in stress-induced transposable element activation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Using genetics to understand biology.Heredity · 2019Review
- Efficient Expression of Genes in theGenetics · 2018Article
- H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.Development (Cambridge, England) · 2017Article
- Feeding-Related Traits Are Affected by Dosage of the foraging Gene in Drosophila melanogaster.Genetics · 2017Article
- Oligopeptide Transporters of the SLC15 Family Are Dispensable for Peptidoglycan Sensing and Transport in Drosophila.Journal of innate immunity · 2017Article
- Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP.Frontiers in molecular neuroscience · 2017Article
- Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development.PLoS genetics · 2017Article
- A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Interplay between RNA interference and heat shock response systems in Drosophila melanogaster.Open biology · 2016Article
- Tissue-Specific Regulation of Drosophila NF-x03BA;B Pathway Activation by Peptidoglycan Recognition Protein SC.Journal of innate immunity · 2016Article
- Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes.Open biology · 2015Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Homologous recombination can produce directed mutations in the genomes of a number of model organisms, including Drosophila melanogaster. One of the most useful applications has been to delete target genes to generate null alleles. In Drosophila, specific gene deletions have not yet been produced by this method. To test whether such deletions could be produced by homologous recombination in D. melanogaster we set out to delete the Hsp70 genes. Six nearly identical copies of this gene, encoding the major heat-shock protein in Drosophila, are found at two separate but closely linked loci. This arrangement has thwarted standard genetic approaches to generate an Hsp70-null fly, making this an ideal test of gene targeting. In this study, ends-out targeting was used to generate specific deletions of all Hsp70 genes, including one deletion that spanned approximately 47 kb. The Hsp70-null flies are viable and fertile. The results show that genomic deletions of varied sizes can be readily generated by homologous recombination in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.