ArticleGenetics2004
Evolutionarily stable infection by a male-killing endosymbiont in Drosophila innubila: molecular evidence from the host and parasite genomes.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed.
- Evolutionary Diversification and Functions of the Candidate Male Killing Gene wmk.Genome biology and evolution · 2025Article
- Prevalence of Heritable Symbionts in Parisian Bedbugs (Hemiptera: Cimicidae).Environmental microbiology reports · 2025Article
- Describing endosymbiont-host interactions within the parasitism-mutualism continuum.Ecology and evolution · 2024Article
- Maintenance and Evaluation of Wolbachia Male-Killers of Dipterans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A male-killing Wolbachia endosymbiont is concealed by another endosymbiont and a nuclear suppressor.PLoS biology · 2023Article
- Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia.Molecular biology and evolution · 2022Article
- Two Newly IntroducedApplied and environmental microbiology · 2021Article
- A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO geneeLife · 2021Article
- Wolbachia-driven selective sweep in a range expanding insect species.BMC ecology and evolution · 2021Article
- Frequent Drivers, Occasional Passengers: Signals of Symbiont-Driven Seasonal Adaptation and Hitchhiking in the Pea Aphid,Insects · 2021Article
- A Review:Vaccines · 2021Review
- Adaptation, ancestral variation and gene flow in a 'Sky Island' Drosophila species.Molecular ecology · 2021Article
- Blind killing of both male and female Drosophila embryos by a natural variant of the endosymbiotic bacterium Spiroplasma poulsonii.Cellular microbiology · 2020Article
- Towards a synthesis of the Caribbean biogeography of terrestrial arthropods.BMC evolutionary biology · 2020Article
- Wolbachia infection in Argentinean populations of Anastrepha fraterculus sp1: preliminary evidence of sex ratio distortion by one of two strains.BMC microbiology · 2019Article
- The phage gene wmk is a candidate for male killing by a bacterial endosymbiont.PLoS pathogens · 2019Article
- The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes.Molecular biology and evolution · 2019Article
- Contrasting Patterns of Virus Protection and Functional Incompatibility Genes in Two ConspecificApplied and environmental microbiology · 2019Article
- A phylogenetic examination of host use evolution in the quinaria and testacea groups of Drosophila.Molecular phylogenetics and evolution · 2019Article
- Common and unique strategies of male killing evolved in two distinctProceedings. Biological sciences · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternally inherited microbes that spread via male-killing are common pathogens of insects, yet very little is known about the evolutionary duration of these associations. The few examples to date indicate very recent, and thus potentially transient, infections. A male-killing strain of Wolbachia has recently been discovered in natural populations of Drosophila innubila. The population-level effects of this infection are significant: approximately 35% of females are infected, infected females produce very strongly female-biased sex ratios, and the resulting population-level sex ratio is significantly female biased. Using data on infection prevalence and Wolbachia transmission rates, infected cytoplasmic lineages are estimated to experience a approximately 5% selective advantage relative to uninfected lineages. The evolutionary history of this infection was explored by surveying patterns of polymorphism in both the host and parasite genomes, comparing the Wolbachia wsp gene and the host mtDNA COI gene to five host nuclear genes. Molecular data suggest that this male-killing infection is evolutionarily old, a conclusion supported with a simple model of parasite and mtDNA transmission dynamics. Despite a large effective population size of the host species and strong selection to evolve resistance, the D. innubila-Wolbachia association is likely at a stable equilibrium that is maintained by imperfect maternal transmission of the bacteria rather than partial resistance in the host species.
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