ArticleGenetics2004
Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Comparative analysis of VMT genes/proteins in selected plant species with emphasis on bread wheat (Triticum aestivum L.).Genes & genomics · 2023Article
- Birth and death of Mx genes and the presence/absence of genes regulating Mx transcription are correlated with the diversity of anti-pathogenicity in vertebrate species.Molecular genetics and genomics : MGG · 2019Article
- A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.EMBO reports · 2019Article
- Genes Relocated Between Drosophila Chromosome Arms Evolve Under Relaxed Selective Constraints Relative to Non-Relocated Genes.Journal of molecular evolution · 2018Article
- Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism.Scientific reports · 2018Article
- Evolutionary Conservation and Emerging Functional Diversity of the Cytosolic Hsp70:J Protein Chaperone Network ofG3 (Bethesda, Md.) · 2017Article
- Article
- Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila.Molecular biology and evolution · 2014Article
- Article
- Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Type-I prenyl protease function is required in the male germline of Drosophila melanogaster.G3 (Bethesda, Md.) · 2012Article
- Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels.Molecular & cellular proteomics : MCP · 2012Article
- Sex and speciation: Drosophila reproductive tract proteins- twenty five years later.International journal of evolutionary biology · 2012Article
- Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling.BMC genomics · 2011Article
- Adaptive evolution of genes duplicated from the Drosophila pseudoobscura neo-X chromosome.Molecular biology and evolution · 2010Article
- Tubulin evolution in insects: gene duplication and subfunctionalization provide specialized isoforms in a functionally constrained gene family.BMC evolutionary biology · 2010Article
- Evolution and functional divergence of NLRP genes in mammalian reproductive systems.BMC evolutionary biology · 2009Article
- Transcript profiling provides evidence of functional divergence and expression networks among ribosomal protein gene paralogs in Brassica napus.The Plant cell · 2009Article
- Gene family evolution across 12 Drosophila genomes.PLoS genetics · 2007Article
- Tandem repetitive D domains of the sperm ligand zonadhesin evolve faster in the paralogue than in the orthologue comparison.Journal of molecular evolution · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication is an important mechanism for acquiring new genes and creating genetic novelty in organisms. Evidence suggests that duplicated genes are retained at a much higher rate than originally thought and that functional divergence of gene copies is a major factor promoting their retention in the genome. We find that two Drosophila testes-specific alpha4 proteasome subunit genes (alpha4-t1 and alpha4-t2) have a higher polymorphism within species and are significantly more diverged between species than the somatic alpha4 gene. Our data suggest that following gene duplication, the alpha4-t1 gene experienced relaxed selective constraints, whereas the alpha4-t2 gene experienced positive selection acting on several codons. We report significant heterogeneity in evolutionary rates among all three paralogs at homologous codons, indicating that functional divergence has coincided with genic divergence. Reproductive subfunctionalization may allow for a more rapid evolution of reproductive traits and a greater specialization of testes function. Our data add to the increasing evidence that duplicated genes experience lower selective constraints and in some cases positive selection following duplication. Newly duplicated genes that are freer from selective constraints may provide a mechanism for developing new interactions and a pathway for the evolution of new genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.