ArticleGenetics2004
Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Structural and physiological functions ofHeliyon · 2024Review
- A PAX6-regulated receptor tyrosine kinase pairs with a pseudokinase to activate immune defense upon oomycete recognition inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- AnmicroPublication biology · 2023Article
- Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification.PLoS genetics · 2022Article
- CEPsh glia development is not required for general AWC identity or AWC asymmetry.microPublication biology · 2022Article
- High-speed label-free confocal microscopy ofBiomedical optics express · 2021Article
- Article
- Regulating distal tip cell migration in space and time.Mechanisms of development · 2017Review
- Phenotypic plasticity and remodeling in the stress-induced Caenorhabditis elegans dauer.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans.Developmental biology · 2016Article
- Pax2/5/8 and Pax6 alternative splicing events in basal chordates and vertebrates: a focus on paired box domain.Frontiers in genetics · 2015Article
- Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences.PLoS genetics · 2013Article
- Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.Genes & development · 2007Article
- The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.Wiley interdisciplinary reviews. Developmental biologyReview
- The Caenorhabditis elegans epidermis as a model skin. I: development, patterning, and growth.Wiley interdisciplinary reviews. Developmental biologyReview
- CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
PAX-6 proteins are involved in eye and brain development in many animals. In the nematode Caenorhabditis elegans the pax-6 locus encodes multiple PAX-6 isoforms both with and without a paired domain. Mutations in the C. elegans pax-6 locus can be grouped into three classes. Mutations that affect paired domain-containing isoforms cause defects in epidermal morphogenesis, epidermal cell fates, and gonad cell migration and define the class I (vab-3) complementation group. The class II mutation mab-18(bx23) affects nonpaired domain-containing isoforms and transforms the fate of a sensory organ in the male tail. Class III mutations affect both paired domain and nonpaired domain isoforms; the most severe class III mutations are candidate null mutations in pax-6. Class III mutant phenotypes do not resemble a simple sum of class I and class II phenotypes. A comparison of class I and class III phenotypes indicates that PAX-6 isoforms can interact additively, synergistically, or antagonistically, depending on the cellular context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.