ArticleGenetics2004
Compartmentalization of the yeast meiotic nucleus revealed by analysis of ectopic recombination.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Non-coding DNA dynamics and its roles as a physical barrier in genome safeguarding across early development and evolution.Heredity · 2026Review
- Gathering up meiotic telomeres: a novel function of the microtubule-organizing center.Cellular and molecular life sciences : CMLS · 2014Review
- Chromosome movement in meiosis I prophase of Caenorhabditis elegans.Chromosoma · 2014Review
- Linkage map of the peppered moth, Biston betularia (Lepidoptera, Geometridae): a model of industrial melanism.Heredity · 2013Article
- Meiotic development in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.PLoS computational biology · 2012Article
- Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formation.PLoS genetics · 2012Article
- Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination.PLoS genetics · 2010Article
- Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.PLoS biology · 2010Article
- Evolutionary dynamics of rDNA clusters on chromosomes of moths and butterflies (Lepidoptera).Genetica · 2010Article
- Genome destabilization by homologous recombination in the germ line.Nature reviews. Molecular cell biology · 2010Review
- Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections?Trends in cell biology · 2009Review
- Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.PLoS genetics · 2008Article
- Prelude to a division.Annual review of cell and developmental biology · 2008Review
- Article
- MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The meiotic bouquet promotes homolog interactions and restricts ectopic recombination in Schizosaccharomyces pombe.Genetics · 2006Article
- Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae.Genetics · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
As yeast cells enter meiosis, chromosomes move from a centromere-clustered (Rabl) to a telomere-clustered (bouquet) configuration and then to states of progressive homolog pairing where telomeres are more dispersed. It is uncertain at which stage of this process sequences commit to recombine with each other. Previous analyses using recombination between dispersed homologous sequences (ectopic recombination) support the view that, on average, homologs are aligned end to end by the time of commitment to recombination. We have undertaken further analyses incorporating new inserts, chromosome rearrangements, an alternate mode of recombination initiation, and mutants that disrupt nuclear structure or telomere metabolism. Our findings support previous conclusions and reveal that distance from the nearest telomere is an important parameter influencing recombination between dispersed sequences. In general, the farther dispersed sequences are from their nearest telomere, the less likely they are to engage in ectopic recombination. Neither the mode of initiating recombination nor the formation of the bouquet appears to affect this relationship. We suggest that aspects of telomere localization and behavior influence the organization and mobility of chromosomes along their entire length, during a critical period of meiosis I prophase that encompasses the homology search.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.