ArticleEnvironmental health perspectives2004
The sources of inflammatory mediators in the lung after silica exposure.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Risk characterization for silica-related silicosis and lung cancer in communities adjacent to sand and gravel extraction facilities: examining limitations in our current risk methods.Frontiers in public health · 2025Article
- Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases.Heliyon · 2023Review
- Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages.Particle and fibre toxicology · 2021Article
- Macrophage-derived exosomes mediate silica-induced pulmonary fibrosis by activating fibroblast in an endoplasmic reticulum stress-dependent manner.Journal of cellular and molecular medicine · 2021Article
- Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure.Toxicology reports · 2019Article
- circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.Theranostics · 2018Article
- MCPIP1 Regulates Alveolar Macrophage Apoptosis and Pulmonary Fibroblast Activation After in vitro Exposure to Silica.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Scientific reports · 2015Article
- Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studies.Toxicology · 2015Article
- Article
- Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells.Particle and fibre toxicology · 2012Article
- NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells.Particle and fibre toxicology · 2010Article
- Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies.Particle and fibre toxicology · 2010Article
- Critical role of MARCO in crystalline silica-induced pulmonary inflammation.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter.Environmental health perspectives · 2006Article
- Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure.Environmental health perspectives · 2006Article
- Time course of gene expression of inflammatory mediators in rat lung after diesel exhaust particle exposure.Environmental health perspectives · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of 10 genes implicated in regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in vivo. Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. AMs isolated after intratracheal instillation of silica up-regulated mRNA levels of four additional genes [granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-1beta, IL-10, and inducible nitric oxide synthase]. IL-6, MCP-1, and MIP-2 protein levels were elevated in bronchoalveolar lavage fluid. Fibroblasts under basal culture conditions express much higher levels of IL-6 and GM-CSF compared with AMs. Coculture of AMs and alveolar type II cells, or coculture of AMs and lung fibroblasts, in contact cultures or Transwell chambers, revealed no synergistic effect. Therefore, such interaction does not explain the effects seen in vivo. Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.