ArticleBMC neuroscience2004
Chloride equilibrium potential in salamander cones.
Article in BMC neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- An EAAT2b/SLC1A2b-mediated chloride leak current enables rapid cone photoreceptor signalling.Open biology · 2025Article
- The Role of the CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells.Vision research · 2021Article
- Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021Review
- Cellular Physiology and Pathophysiology of EAAT Anion Channels.Frontiers in cellular neuroscience · 2021Review
- Contributions of glutamate transporters and CaExperimental eye research · 2019Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Feedback-induced glutamate spillover enhances negative feedback from horizontal cells to cones.The Journal of physiology · 2015Article
- Sign-preserving and sign-inverting synaptic interactions between rod and cone photoreceptors in the dark-adapted retina.The Journal of physiology · 2013Article
- Regulation of synaptic transmission at the photoreceptor terminal: a novel role for the cation-chloride co-transporter NKCC1.The Journal of physiology · 2013Article
- Chloride currents in cones modify feedback from horizontal cells to cones in goldfish retina.The Journal of physiology · 2012Article
- Lateral interactions in the outer retina.Progress in retinal and eye research · 2012Review
- The photovoltage of rods and cones in the dark-adapted mouse retina.The Journal of physiology · 2012Article
- A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.PloS one · 2012Article
- Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.Journal of neurophysiology · 2011Article
- Glutamate spillover between mammalian cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.Journal of neurophysiology · 2011Article
- Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors.American journal of physiology. Cell physiology · 2011Article
- TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity.Frontiers in molecular neuroscience · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGABAergic inhibition and effects of intracellular chloride ions on calcium channel activity have been proposed to regulate neurotransmission from photoreceptors. To assess the impact of these and other chloride-dependent mechanisms on release from cones, the chloride equilibrium potential (ECl) was determined in red-sensitive, large single cones from the tiger salamander retinal slice.
resultsWhole cell recordings were done using gramicidin perforated patch techniques to maintain endogenous Cl- levels. Membrane potentials were corrected for liquid junction potentials. Cone resting potentials were found to average -46 mV. To measure ECl, we applied long depolarizing steps to activate the calcium-activated chloride current (ICl(Ca)) and then determined the reversal potential for the current component that was inhibited by the Cl- channel blocker, niflumic acid. With this method, ECl was found to average -46 mV. In a complementary approach, we used a Cl-sensitive dye, MEQ, to measure the Cl- flux produced by depolarization with elevated concentrations of K+. The membrane potentials produced by the various high K+ solutions were measured in separate current clamp experiments. Consistent with electrophysiological experiments, MEQ fluorescence measurements indicated that ECl was below -36 mV.
conclusionsThe results of this study indicate that ECl is close to the dark resting potential. This will minimize the impact of chloride-dependent presynaptic mechanisms in cone terminals involving GABAa receptors, glutamate transporters and ICl(Ca).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.