ReviewPflugers Archiv : European journal of physiology2004
The bile salt export pump: molecular properties, function and regulation.
Review in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis.Molecular immunology · 2024Article
- Association of Drug-Metabolizing Enzyme and Transporter Gene Polymorphisms and Lipid-Lowering Response to Statins in Thai Patients with Dyslipidemia.Pharmacogenomics and personalized medicine · 2022Article
- Keratin 7 expression in hepatic cholestatic diseases.Virchows Archiv : an international journal of pathology · 2021Article
- Aluminum Exposure from Parenteral Nutrition: Early Bile Canaliculus Changes of the Hepatocyte.Nutrients · 2018Article
- Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts.Scientific reports · 2017Article
- Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts.BioMed research international · 2014Review
- Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Hepatology (Baltimore, Md.) · 2009Article
- Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).The AAPS journal · 2009Review
- Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease.Expert opinion on drug metabolism & toxicology · 2009Review
- OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.Frontiers in bioscience (Landmark edition) · 2009Review
- Regulation of hepatic bile acid transporters Ntcp and Bsep expression.Biochemical pharmacology · 2007Article
- Bile acid transporters: structure, function, regulation and pathophysiological implications.Pharmaceutical research · 2007Review
- Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats.European journal of drug metabolism and pharmacokineticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Secretion of bile salts from the hepatocyte into bile is the major driving force for the generation of bile flow. Identification of the bile salt export pump (BSEP, ABCB11) as the main adenosine-triphosphate-dependent bile salt transporter in mammalian liver has led to a greater understanding of the biliary bile salt secretory process and its regulation. The biology and pathobiology of BSEP have been the subject of many recent studies. Thus, it has been recognized that while mutations in the gene encoding BSEP are responsible for a subgroup of progressive familial cholestasis (progressive familial intrahepatic cholestasis subtype 2), a pediatric cholestatic disorder that may progress to cirrhosis, defective expression or function of BSEP may underlie some forms of drug-induced cholestasis. The present review summarizes recent data on the molecular properties and regulation of BSEP, as well as the clinical implications of absent or defective function of this hepatic efflux pump.
Indexed as
Identifiers
15578267What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.