ArticleHuman genetics2005
Variation in meiotic recombination frequencies among human males.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Article
- Unraveling haplotype errors in the DFNA33 locus.Frontiers in genetics · 2023Article
- Recombination correlates with synaptonemal complex length and chromatin loop size in bovids-insights into mammalian meiotic chromosomal organization.Chromosoma · 2017Article
- Mammalian Comparative Genomics Reveals Genetic and Epigenetic Features Associated with Genome Reshuffling in Rodentia.Genome biology and evolution · 2016Article
- Evaluation of mRNA Contents of YBX2 and JHDM2A Genes on Testicular Tissues of Azoospermic Men with Different Classes of Spermatogenesis.Cell journal · 2015Article
- Cytogenetic and molecular analyses of de novo translocation dic(9;13)(p11.2;p12) in an infertile male.Molecular cytogenetics · 2014Article
- Meiotic prophase I defects in an oligospermic man with Wolf-Hirschhorn syndrome with ring chromosome 4.Molecular cytogenetics · 2014Article
- Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory.Molecular biology and evolution · 2013Article
- Analysis of human meiotic recombination events with a parent-sibling tracing approach.BMC genomics · 2011Article
- Meiotic recombination and male infertility: from basic science to clinical reality?Asian journal of andrology · 2011Review
- Altered microRNA expression in patients with non-obstructive azoospermia.Reproductive biology and endocrinology : RB&E · 2009Article
- Variation in patterns of human meiotic recombination.Genome dynamics · 2009Review
- Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.Human reproduction (Oxford, England) · 2008Article
- Article
- General pattern of meiotic recombination in male dogs estimated by MLH1 and RAD51 immunolocalization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Meiotic recombination and spatial proximity in the etiology of the recurrent t(11;22).American journal of human genetics · 2006Article
- The synaptonemal complex and meiotic recombination in humans: new approaches to old questions.Chromosoma · 2006Review
- Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male.American journal of human genetics · 2005Article
- The association of stromal antigen 3 (STAG3) sequence variations with spermatogenic impairment in the male Korean population.Asian journal of andrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination is essential for the segregation of homologous chromosomes and the formation of normal haploid gametes. Little is known about patterns of meiotic recombination in human germ cells or the mechanisms that control these patterns. Here, newly developed immunofluorescence techniques, based on the detection of MLH1 (a DNA mismatch repair protein) foci on synaptonemal complexes (SCs) at prophase I of meiosis, were used to examine recombination in human spermatocytes. The mean number of MLH1 foci per cell in all donors was 48.0 with range from 21 to 65. Remarkable variation in the recombination frequency was noted among 11 normal individuals: the mean frequencies of chromosomal recombination foci ranged from a low of 42.5 to a high of 55.0 exchanges. Donor age did not contribute to this variation. There was no correlation between this variation and the frequency of gaps (discontinuities) or splits (unpaired chromosome regions) in the SCs. The mean percentage of cells with gaps was 35% (range: 20% to 58%) and with splits was 7% (range: 0% to 37%). Bivalents without a recombination focus were rare, with a frequency of only 0.3%. Thus, achiasmate chromosomes appear to be rare in human male meiosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.