ArticleImmunogenetics2005
Considerable haplotypic diversity in the RT1-CE class I gene region of the rat major histocompatibility complex.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Nomenclature report on the major histocompatibility complex genes and alleles of the laboratory rat (Rattus norvegicus).Immunogenetics · 2020Review
- Review
- Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- CD8αα+MHC Class II+ Cell with the Capacity To Terminate Autoimmune Inflammation Is a Novel Antigen-Presenting NK-like Cell in Rats.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease.G3 (Bethesda, Md.) · 2013Article
- Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA.PloS one · 2011Article
- MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.Proceedings. Biological sciences · 2010Article
- Influence of major histocompatibility complex genotype on mating success in a free-ranging reptile population.Proceedings. Biological sciences · 2009Article
- Pas de deux: natural killer receptors and MHC class I ligands in primates.Current genomics · 2007Article
- BoLA class I allele diversity and polymorphism in a herd of cattle.Immunogenetics · 2007Article
- Generation and maintenance of diversity in the cattle MHC class I region.Immunogenetics · 2006Article
- Polymorphism of two very similar MHC class Ib loci in rainbow trout (Oncorhynchus mykiss).Immunogenetics · 2006Article
- ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005.Immunogenetics · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histocompatibility complex (MHC) class I region extending between the Bat1 and Pou5f1 genes shows considerable genomic plasticity in mouse and rhesus macaque but not in human haplotypes. In the rat, this region is known as the RT1-CE region. The recently published rat MHC sequence gave rise to a complete set of class I gene sequences in a single MHC haplotype, namely the RT1(n) haplotype of the widely used BN inbred strain. To study the degree of genetic diversity, we compared the RT1-CE region-derived class I genes of the RT1(n) haplotype with class I sequences of other rat haplotypes. By using phylogenetic tree analyses, we obtained evidence for extensive "presence and absence" polymorphisms of single loci and even small subfamilies of class I genes in the rat. Alleles of RT1-CE region class I genes could also be identified, but the rate of allelic nucleotide substitutions appeared rather low, indicating that the diversity in the RT1-CE region is mainly based on genomic plasticity.
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