ArticleThe Journal of clinical investigation2004
The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barre syndrome.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 198 citations in OpenAlex.
- Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells.The Journal of biological chemistry · 2026Article
- Virulence and Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Glycoconjugate diversification inbioRxiv : the preprint server for biology · 2026Article
- Comparative immunoproteomics ofFrontiers in cellular and infection microbiology · 2026Article
- Specific gut microbiota alterations and metabolic deficits in Parkinson's disease: a controlled comparison with functional constipation.Frontiers in cellular and infection microbiology · 2026Article
- Guillain-Barré Syndrome: Progress in Diagnosis, Biomarkers, Neuroimaging and Management.ImmunoTargets and therapy · 2026Review
- Cas9 modulatesMicrobiology (Reading, England) · 2025Article
- Major Foodborne Bacterial Pathogens in Poultry: Implications for Human Health and the Poultry Industry and Probiotic Mitigation Strategies.Microorganisms · 2025Review
- Genomic variability of lipooligosaccharide biosynthesis locus and sequence type amongMicrobiology spectrum · 2025Article
- Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells.PLoS neglected tropical diseases · 2025Article
- Comparative genomic analysis of Flavobacterium species causing columnaris disease of freshwater fish in Thailand: insights into virulence and resistance mechanisms.BMC veterinary research · 2025Article
- Pathogenicity and virulence ofVirulence · 2024Review
- Glycoengineering with neuraminic acid analogs to label lipooligosaccharides and detect native sialyltransferase activity in gram-negative bacteria.Glycobiology · 2024Article
- The Transmission ofPathogens (Basel, Switzerland) · 2024Article
- Interleukin-10 promoter polymorphisms and haplotypes in patients with Guillain-Barré syndrome.Annals of clinical and translational neurology · 2024Article
- Discovery and characterization of a novel pathogenFrontiers in microbiology · 2024Article
- Whole-genome-based characterization ofMicrobial genomics · 2023Article
- Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation.International journal of molecular sciences · 2022Review
- Molecular and in silico typing of the lipooligosaccharide biosynthesis gene cluster in Campylobacter jejuni and Campylobacter coli.PloS one · 2022Article
- Biological functions of sialic acid as a component of bacterial endotoxin.Frontiers in microbiology · 2022Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular mimicry of Campylobacter jejuni lipo-oligosaccharides (LOS) with gangliosides in nervous tissue is considered to induce cross-reactive antibodies that lead to Guillain-Barre syndrome (GBS), an acute polyneuropathy. To determine whether specific bacterial genes are crucial for the biosynthesis of ganglioside-like structures and the induction of anti-ganglioside antibodies, we characterized the C. jejuni LOS biosynthesis gene locus in GBS-associated and control strains. We demonstrated that specific types of the LOS biosynthesis gene locus are associated with GBS and with the expression of ganglioside-mimicking structures. Campylobacter knockout mutants of 2 potential GBS marker genes, both involved in LOS sialylation, expressed truncated LOS structures without sialic acid, showed reduced reactivity with GBS patient serum, and failed to induce an anti-ganglioside antibody response in mice. We demonstrate, for the first time, to our knowledge, that specific bacterial genes are crucial for the induction of anti-ganglioside antibodies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.