ArticleThe Journal of clinical investigation2004
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 97 citations in OpenAlex.
- Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- In vivo myomaker-mediated heterologous fusion and nuclear reprogramming.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells.Stem cell reports · 2016Article
- Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A.Skeletal muscle · 2015Article
- Limb-girdle muscular dystrophies: where next after six decades from the first proposal (Review).Molecular medicine reports · 2014Review
- Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Skeletal Muscle-derived Hematopoietic Stem Cells: Muscular Dystrophy Therapy by Bone Marrow Transplantation.Journal of stem cell research & therapy · 2012Article
- Human adipose tissue-derived stem cells exhibit proliferation potential and spontaneous rhythmic contraction after fusion with neonatal rat cardiomyocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Diabetes and aging alter bone marrow contributions to tissue maintenance.International journal of physiology, pathophysiology and pharmacology · 2009Article
- The origin, molecular regulation and therapeutic potential of myogenic stem cell populations.Journal of anatomy · 2009Review
- Sarcoglycanopathies: molecular pathogenesis and therapeutic prospects.Expert reviews in molecular medicine · 2009Review
- Donor-derived hematopoietic cell contribution to myofibers in acid alpha-glucosidase deficiency: a promising progress or back to the beginning?The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Stem cells for heart cell therapies.Tissue engineering. Part B, Reviews · 2008Article
- Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy.The American journal of pathology · 2008Article
- Cell-lineage regulated myogenesis for dystrophin replacement: a novel therapeutic approach for treatment of muscular dystrophy.Human molecular genetics · 2008Article
- Deciphering the beta-adrenergic response in human embryonic stem cell-derived-cardiac myocytes: closer to clinical use?British journal of pharmacology · 2008Article
- Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes.Developmental biology · 2007Article
- Reflections on lineage potential of skeletal muscle satellite cells: do they sometimes go MAD?Critical reviews in eukaryotic gene expression · 2007Review
- Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters.The American journal of pathology · 2006Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotent bone marrow-derived side population (BM-SP) stem cells have been shown to repopulate the hematopoietic system and to contribute to skeletal and cardiac muscle regeneration after transplantation. We tested BM-SP cells for their ability to regenerate heart and skeletal muscle using a model of cardiomyopathy and muscular dystrophy that lacks delta-sarcoglycan. The absence of delta-sarcoglycan produces microinfarcts in heart and skeletal muscle that should recruit regenerative stem cells. Additionally, sarcoglycan expression after transplantation should mark successful stem cell maturation into cardiac and skeletal muscle lineages. BM-SP cells from normal male mice were transplanted into female delta-sarcoglycan-null mice. We detected engraftment of donor-derived stem cells into skeletal muscle, with the majority of donor-derived cells incorporated within myofibers. In the heart, donor-derived nuclei were detected inside cardiomyocytes. Skeletal muscle myofibers containing donor-derived nuclei generally failed to express sarcoglycan, with only 2 sarcoglycan-positive fibers detected in the quadriceps muscle from all 14 mice analyzed. Moreover, all cardiomyocytes with donor-derived nuclei were sarcoglycan-negative. The absence of sarcoglycan expression in cardiomyocytes and skeletal myofibers after transplantation indicates impaired differentiation and/or maturation of bone marrow-derived stem cells. The inability of BM-SP cells to express this protein severely limits their utility for cardiac and skeletal muscle regeneration.
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