ArticleThe Journal of clinical investigation2004
Marfan syndrome and mitral valve prolapse.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Lymphatic dysfunction and ZFP36 deficiency contribute to myxomatous valve degeneration in Marfan syndrome mice.The Journal of clinical investigation · 2026Article
- Immune Mechanisms of Heart Valve Development, Homeostasis, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse.Communications medicine · 2024Article
- Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets.Progress in retinal and eye research · 2022Article
- Meary angle for the prediction of mitral valve prolapse risk in non-syndromic patients with pes planus, a cross-sectional study.BMC research notes · 2022Article
- Should mitral valve prolapse be considered as one of the risk factors for open angle glaucoma? A preliminary observation.International journal of ophthalmology · 2022Article
- Identification of Patients Affected by Mitral Valve Prolapse with Severe Regurgitation: A Multivariable Regression Model.Oxidative medicine and cellular longevity · 2017Observational
- Echocardiographic versus histologic findings in Marfan syndrome.Texas Heart Institute journal · 2015Article
- Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.Journal of cardiovascular translational research · 2014Review
- Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice.American journal of respiratory cell and molecular biology · 2012Article
- Differentiating the aging of the mitral valve from human and canine myxomatous degeneration.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2012Review
- Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome.PloS one · 2012Article
- Heart valve structure and function in development and disease.Annual review of physiology · 2011Review
- Heart valve development: regulatory networks in development and disease.Circulation research · 2009Review
- Applying elastic fibre biology in vascular tissue engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
- Adult women with mitral valve prolapse are more flexible.British journal of sports medicine · 2005Article
- Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease.Cardiovascular pathology : the official journal of the Society for Cardiovascular PathologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP. This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.