ArticleJournal of bacteriology2004
The etiological agent of Lyme disease, Borrelia burgdorferi, appears to contain only a few small RNA molecules.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Virulence Regulation inMicroorganisms · 2025Review
- Potential Regulatory Role in Mammalian Host Adaptation for a Small Intergenic Region of Lp17 in the Lyme Disease Spirochete.Frontiers in cellular and infection microbiology · 2022Article
- The intergenic small non-coding RNA ittA is required for optimal infectivity and tissue tropism in Borrelia burgdorferi.PLoS pathogens · 2020Article
- Transcriptional profiling of Rickettsia prowazekii coding and non-coding transcripts during in vitro host-pathogen and vector-pathogen interactions.Ticks and tick-borne diseases · 2017Article
- Article
- CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi.Infection and immunity · 2011Article
- Stem loop sequences specific to transposable element IS605 are found linked to lipoprotein genes in Borrelia plasmids.PloS one · 2009Article
- A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus.PloS one · 2009Article
- Evidence that two ATP-dependent (Lon) proteases in Borrelia burgdorferi serve different functions.PLoS pathogens · 2009Article
- Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of Borrelia burgdorferi.Infection and immunity · 2009Article
- Intergenic regions of Borrelia plasmids contain phylogenetically conserved RNA secondary structure motifs.BMC genomics · 2009Article
- Small non-coding RNAs in Caulobacter crescentus.Molecular microbiology · 2008Article
- No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureus.BMC microbiology · 2007Article
- Borrelia burgdorferi ftsZ plays a role in cell division.Journal of bacteriology · 2006Article
- Genes for small, noncoding RNAs under sporulation control in Bacillus subtilis.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small regulatory RNAs (sRNAs) have recently been shown to be the main controllers of several regulatory pathways. The function of sRNAs depends in many cases on the RNA-binding protein Hfq, especially for sRNAs with an antisense function. In this study, the genome of Borrelia burgdorferi was subjected to different searches for sRNAs, including direct homology and comparative genomics searches and ortholog- and annotation-based search strategies. Two new sRNAs were found, one of which showed complementarity to the rpoS region, which it possibly controls by an antisense mechanism. The role of the other sRNA is unknown, although observed complementarities against particular mRNA sequences suggest an antisense mechanism. We suggest that the low level of sRNAs observed in B. burgdorferi is at least partly due to the presumed lack of both functional Hfq protein and RNase E activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.