ArticleJournal of bacteriology2004
The RpoH-mediated stress response in Neisseria gonorrhoeae is regulated at the level of activity.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.Nature communications · 2024Article
- Transcriptional regulation of theMicrobiology (Reading, England) · 2022Review
- Contribution of σJournal of bacteriology · 2019Article
- Conservation of Ancient Genetic Pathways for Intracellular Persistence Among Animal Pathogenic Bordetellae.Frontiers in microbiology · 2019Article
- Neisseria gonorrhoeae host adaptation and pathogenesis.Nature reviews. Microbiology · 2018Review
- Article
- Purification and biochemical characterization of DnaK and its transcriptional activator RpoH from Neisseria gonorrhoeae.Molecular biology reports · 2014Article
- Identification of sRNAs expressed by the human pathogen Neisseria gonorrhoeae under disparate growth conditions.Frontiers in microbiology · 2014Article
- Transcriptional landscape and essential genes of Neisseria gonorrhoeae.Nucleic acids research · 2014Article
- Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae.BMC genomics · 2011Article
- Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH.Microbiology (Reading, England) · 2009Article
- MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae.Journal of bacteriology · 2009Article
- MisR/MisS two-component regulon in Neisseria meningitidis.Infection and immunity · 2008Article
- Transposon mutagenesis identifies sites upstream of the Neisseria gonorrhoeae pilE gene that modulate pilin antigenic variation.Journal of bacteriology · 2007Article
- Comparison of the RpoH-dependent regulon and general stress response in Neisseria gonorrhoeae.Journal of bacteriology · 2006Article
- Ecf, an alternative sigma factor from Neisseria gonorrhoeae, controls expression of msrAB, which encodes methionine sulfoxide reductase.Journal of bacteriology · 2006Article
- Effect of Neisseria meningitidis fur mutations on global control of gene transcription.Journal of bacteriology · 2006Article
- The heat shock genes dnaK, dnaJ, and grpE are involved in regulation of putisolvin biosynthesis in Pseudomonas putida PCL1445.Journal of bacteriology · 2005Article
- Global gene expression and the role of sigma factors in Neisseria gonorrhoeae in interactions with epithelial cells.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The general stress response in Neisseria gonorrhoeae was investigated. Transcriptional analyses of the genes encoding the molecular chaperones DnaK, DnaJ, and GrpE suggested that they are transcribed from sigma32 (RpoH)-dependent promoters upon exposure to stress. This was confirmed by mutational analysis of the sigma32 promoter of dnaK. The gene encoding the gonococcal RpoH sigma factor appears to be essential, as we could not isolate viable mutants. Deletion of an unusually long rpoH leader sequence resulted in elevated levels of transcription, suggesting that this region is involved in negative regulation of RpoH expression during normal growth. Transcriptional analyses and protein studies determined that regulation of the RpoH-mediated stress response is different from that observed in most other species, in which regulation occurs predominantly at the transcriptional and translational levels. We suggest that an increase in the activity of preformed RpoH is primarily responsible for induction of the stress response in N. gonorrhoeae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.