Evidence map›Paper›PMID 15576788›Full record

ArticleJournal of bacteriology2004

Gene ytkD of Bacillus subtilis encodes an atypical nucleoside triphosphatase member of the Nudix hydrolase superfamily.

Wenlian Xu, Candice R Jones, Christopher A Dunn, Maurice J Bessman

Abstract read
In one paragraph

Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
  3. YvcI fromThe Journal of biological chemistry · 2019
    Article
  4. An endogenous dAMP ligand inProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Initiation of mRNA decay in bacteria.Cellular and molecular life sciences : CMLS · 2014
    Review
  11. Article
  12. DNA repair and genome maintenance in Bacillus subtilis.Microbiology and molecular biology reviews : MMBR · 2012
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenlian XuDepartment of Biology, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
Candice R Jones
Christopher A Dunn
Maurice J Bessman
Johns Hopkins University · US

Funding

ENZYMATIC SYNTHESIS OF NUCLEOTIDES AND DNAR01GM018649 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BESSMAN, MAURICE J · 1985 to 2006
$2.3M
COMPACT STRUCTURE IN A DENATURED PROTEINF32GM018649 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SINCLAIR, JAMES F · 1997 to 1998
–
NIGMS NIH HHS F32 GM018649NIGMS NIH HHS GM-18649NIGMS NIH HHS R01 GM018649
6 · The paper itself

Abstract

Gene ytkD of Bacillus subtilis, a member of the Nudix hydrolase superfamily, has been cloned and expressed in Escherichia coli. The purified protein has been characterized as a nucleoside triphosphatase active on all of the canonical ribo- and deoxyribonucleoside triphosphates. Whereas all other nucleoside triphosphatase members of the superfamily release inorganic pyrophosphate and the cognate nucleoside monophosphate, YtkD hydrolyses nucleoside triphosphates in a stepwise fashion through the diphosphate to the monophosphate, releasing two molecules of inorganic orthophosphate. Contrary to a previous report, our enzymological and genetic studies indicate that ytkD is not an orthologue of E. coli mutT.

Indexed as

Bacterial ProteinsNucleoside-TriphosphataseAmino Acid SequenceBacillus subtilisCloning, MolecularEscherichia coli ProteinsGenetic Complementation TestMolecular Sequence DataNudix HydrolasesPhosphoric Monoester HydrolasesPyrophosphatasesSequence Analysis, DNASubstrate SpecificityBacterial ProteinsEscherichia coli ProteinsmutT protein, E coliNucleoside-TriphosphataseNudix HydrolasesPhosphoric Monoester HydrolasesPyrophosphatases

Identifiers

PMID15576788
PMCPMC532436
OpenAlexW15576788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.