ArticleNucleic acids research2004
Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation.Nature communications · 2026Article
- Article
- Caenorhabditis elegans as an emerging model system in environmental epigenetics.Environmental and molecular mutagenesis · 2018Review
- Metagenomic Analysis of Bacteria, Fungi, Bacteriophages, and Helminths in the Gut of Giant Pandas.Frontiers in microbiology · 2018Article
- Evolution of DNMT2 in drosophilids: Evidence for positive and purifying selection and insights into new protein (pathways) interactions.Genetics and molecular biology · 2018Article
- Recruitment of histone modifications to assist mRNA dosage maintenance after degeneration of cytosine DNA methylation during animal evolution.Genome research · 2017Article
- The genetics of phenotypic plasticity in nematode feeding structures.Open biology · 2017Review
- Natural RNA interference directs a heritable response to the environment.Scientific reports · 2014Article
- Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita.Frontiers in physiology · 2014Article
- Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation.Developmental biology · 2013Article
- Introduction: The use of animals models to advance epigenetic science.ILAR journal · 2012Article
- Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.Nature communications · 2011Article
- Article
- Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans.PloS one · 2010Article
- Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans.BMC developmental biology · 2010Article
- Solving the Dnmt2 enigma.Chromosoma · 2010Review
- Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs.Current medicinal chemistry · 2010Review
- Loss of the insulator protein CTCF during nematode evolution.BMC molecular biology · 2009Article
- Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development.The international journal of biochemistry & cell biology · 2009Review
- Evolution of DNA-methylation machinery: DNA methyltransferases and methyl-DNA binding proteins in the amphioxus Branchiostoma floridae.Development genes and evolution · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole genome sequencing of several metazoan model organisms provides a platform for studying genome evolution. How representative are the genomes of these model organisms for their respective phyla? Within nematodes, for example, the free-living soil nematode Caenorhabditis elegans is a highly derived species with unusual genomic characters, such as a reduced Hox cluster (Curr. Biol., 13, 37-40) and the absence of a Hedgehog signaling system. Here, we describe the recent loss of a DNA methyltransferase-2 gene (dnmt-2) in C.elegans. A dnmt-2-like gene is present in the satellite model organism Pristionchus pacificus, another free-living nematode that diverged from C.elegans 200-300 million years ago. In contrast, C.elegans, Caenorhabditis briggsae and P.pacificus all contain an mbd-2-like gene, which encodes another essential component of the methylation system of higher animals and fungi. Cel-mbd-2 is expressed throughout development and RNA interference (RNAi) experiments result in variable phenotypes. In contrast, Cbr-mbd-2 RNAi results in paralyzed larval or adult worms suggesting recent changes of gene function within the genus Caenorhabditis. We speculate that both genes were part of an ancestral DNA methylation system in nematodes and that gene loss and sequence divergence have abolished DNA methylation in C.elegans.
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