ArticleThe Journal of physiology2005
Sympathetic neural inhibition of conducted vasodilatation along hamster feed arteries: complementary effects of alpha1- and alpha2-adrenoreceptor activation.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- The conducted vasomotor response and the principles of electrical communication in resistance arteries.Physiological reviews · 2024Review
- Microvascular mechanisms limiting skeletal muscle blood flow with advancing age.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Vasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone.The Journal of physiology · 2018Article
- Endothelium-dependent vasodilatory signalling modulates αThe Journal of physiology · 2016Article
- Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.American journal of physiology. Heart and circulatory physiology · 2016Article
- Contributions of Central Command and Muscle Feedback to Sympathetic Nerve Activity in Contracting Human Skeletal Muscle.Frontiers in physiology · 2016Article
- Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition.The Journal of physiology · 2015Article
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Cardiovascular control during exercise in type 2 diabetes mellitus.Journal of diabetes research · 2015Review
- Integration and Modulation of Intercellular Signaling Underlying Blood Flow Control.Journal of vascular research · 2015Article
- Aging alters reactivity of microvascular resistance networks in mouse gluteus maximus muscle.American journal of physiology. Heart and circulatory physiology · 2014Article
- The vascular conducted response in cerebral blood flow regulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Perivascular innervation: a multiplicity of roles in vasomotor control and myoendothelial signaling.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Inefficient functional sympatholysis is an overlooked cause of malperfusion in contracting skeletal muscle.The Journal of physiology · 2012Review
- Spreading the signal for vasodilatation: implications for skeletal muscle blood flow control and the effects of ageing.The Journal of physiology · 2012Review
- Intercellular communication in the vascular wall: a modeling perspective.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.British journal of pharmacology · 2012Article
- Regulation of blood flow in the microcirculation: role of conducted vasodilation.Acta physiologica (Oxford, England) · 2011Review
- Modeling Ca2+ signaling in the microcirculation: intercellular communication and vasoreactivity.Critical reviews in biomedical engineering · 2011Review
- Regional heterogeneity of α-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Vasodilatation initiated on arterioles of skeletal muscle ascends into the proximal feed arteries through cell-to-cell conduction along the endothelium and into smooth muscle. Whereas perivascular sympathetic nerve activity (SNA) can inhibit conducted vasodilatation and restrict muscle blood flow, the signalling events mediating this interaction are poorly defined. Therefore, using isolated pressurized (75 mmHg) feed arteries (diameter (microm) at rest = 53 +/- 3; maximum = 99 +/- 2; n = 86) of the hamster retractor muscle, we tested the hypothesis that distinct yet complementary signalling pathways underlie the ability of SNA to inhibit conduction. Conducted vasodilatation was initiated using ACh microiontophoresis (1 microA; 250, 500 and 1000 ms) and SNA was initiated using local field stimulation (30-50 V; 1 ms at 2, 8 and 16 Hz). With vasodilatations of 5-20 microM, conduction increased with ACh pulse duration and was inhibited progressively as the frequency of SNA increased. During SNA, conduction was partially restored with inhibition of alpha1- (0.1 microM prazosin) or alpha2- (0.1 microM RX821002) adrenoreceptors and fully restored with both antagonists present. Activating alpha1- (50 nM phenylephrine) or alpha2- (1 microM UK 14,304) adrenoreceptors inhibited conduction partially and their simultaneous activation inhibited conduction cumulatively (P < 0.05). Elevated [K+]o (30 or 40 mM) or phorbol esters (0.5 microM) also inhibited conduction yet similar constriction with l-NNA (50 microM) or Bay K 8644 (10 nM) did not. Thus, the activation of alpha1- and alpha2-adrenoreceptors inhibits conducted vasodilatation through complementary signalling events. With robust coupling along the endothelium, our modelling predicts that the inhibition of conduction by SNA can be explained by reduced electrical coupling through myoendothelial gap junctions or greater current leak across smooth muscle cell membranes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.