ArticleNucleic acids research2004
Computational method for discovery of estrogen responsive genes.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis.Annals of oncology : official journal of the European Society for Medical Oncology · 2012Review
- In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer.BMC systems biology · 2011Article
- Estrogen-dependent gene expression in the mouse ovary.PloS one · 2011Article
- Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats.Reproductive biology and endocrinology : RB&E · 2010Article
- The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERalpha-mediated transcriptional responses.The Journal of steroid biochemistry and molecular biology · 2010Article
- Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements.Nucleic acids research · 2010Article
- Cellular targets of estrogen signaling in regeneration of inner ear sensory epithelia.Hearing research · 2009Review
- Canonical pathways and networks regulated by estrogen in the bovine mammary gland.Functional & integrative genomics · 2008Article
- Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells.PloS one · 2008Article
- Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer.BMC molecular biology · 2007Article
- Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Genome-wide approaches for identification of nuclear receptor target genes.Nuclear receptor signaling · 2006Article
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Authors and funding
6 authors.
Funding
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Abstract
Estrogen has a profound impact on human physiology and affects numerous genes. The classical estrogen reaction is mediated by its receptors (ERs), which bind to the estrogen response elements (EREs) in target gene's promoter region. Due to tedious and expensive experiments, a limited number of human genes are functionally well characterized. It is still unclear how many and which human genes respond to estrogen treatment. We propose a simple, economic, yet effective computational method to predict a subclass of estrogen responsive genes. Our method relies on the similarity of ERE frames across different promoters in the human genome. Matching ERE frames of a test set of 60 known estrogen responsive genes to the collection of over 18,000 human promoters, we obtained 604 candidate genes. Evaluating our result by comparison with the published microarray data and literature, we found that more than half (53.6%, 324/604) of predicted candidate genes are responsive to estrogen. We believe this method can significantly reduce the number of testing potential estrogen target genes and provide functional clues for annotating part of genes that lack functional information.
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