ArticleJournal of anatomy2004
Actin filament organization in aligned prefusion myoblasts.
Article in Journal of anatomy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- miRNA mediated downregulation of cyclase-associated protein 1 (CAP1) is required for myoblast fusion.Frontiers in cell and developmental biology · 2022Article
- "Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation.Acta physiologica (Oxford, England) · 2021Article
- Actomyosin contractility scales with myoblast elongation and enhances differentiation through YAP nuclear export.Scientific reports · 2019Article
- Shisa2 regulates the fusion of muscle progenitors.Stem cell research · 2018Article
- Vinculin forms a directionally asymmetric catch bond with F-actin.Science (New York, N.Y.) · 2017Article
- GRAF1 promotes ferlin-dependent myoblast fusion.Developmental biology · 2014Article
- Substrate stiffness affects skeletal myoblast differentiationScience and technology of advanced materials · 2012Article
- Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1.The Journal of biological chemistry · 2011Article
- Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair.Journal of anatomy · 2011Article
- Response of an actin filament network model under cyclic stretching through a coarse grained Monte Carlo approach.Journal of theoretical biology · 2011Article
- ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.Molecular biology of the cell · 2010Article
- Forming the cell rear first: breaking cell symmetry to trigger directed cell migration.Nature cell biology · 2010Article
- Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells.Experimental & molecular medicine · 2009Article
- Nap1-mediated actin remodeling is essential for mammalian myoblast fusion.Journal of cell science · 2009Article
- The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Dependence of myoblast fusion on a cortical actin wall and nonmuscle myosin IIA.Developmental biology · 2009Article
- Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts.Molecular biology of the cell · 2008Article
- M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.Molecular biology of the cell · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of the actin cytoskeleton in prefusion aligning myoblasts is likely to be important for their shape and interaction. We investigated actin filament organization and polarity by transmission electron microscopy (TEM) in these cells. About 84% of the filaments counted were either found in a subplasmalemma sheet up to 0.5 microm thick that was aligned with the long axis of the cell, or in protrusions. The remaining filaments were found in the cytoplasm, where they were randomly orientated and not organized into bundles. The polarity of the subplasmalemma filaments changed progressively from one end of the cell to the other. At the ends of the cells and in protrusions, the majority of filaments were organized such that their barbed ends faced the tip of the protrusion. We did not find any actin filament bundles or stress fibres in these cells. Time-lapse phase microscopy demonstrated that aligned cells were still actively migrating at the time of our TEM observations, and their direction of movement was restricted to the long axis of the cell group. The ability of these cells to locomote actively in the absence of actin filament bundles suggests that in these cells the subplasmalemma actin sheet contributes not only to cell shape but also to cell locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.