ArticleApplied and environmental microbiology2004
Identification and functional analysis of the gene encoding methionine-gamma-lyase in Brevibacterium linens.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 98 citations in OpenAlex.
- Isolation and identification of Alcaligenes faecalis W2-3 with high-yield production of dimethyl disulfide.Scientific reports · 2025Article
- Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic Potential.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Quorum Sensing Regulates the Production of Methanethiol inMicroorganisms · 2023Article
- Isolation and characterization ofSaudi journal of biological sciences · 2023Article
- Biochemical, molecular and anti-tumor characterization of L-methionine gamma lyase produced by localSaudi journal of biological sciences · 2023Article
- Causality Verification for the Correlation between the Presence of Nonstarter Bacteria and Flavor Characteristics in Soft-Type Ripened Cheeses.Microbiology spectrum · 2022Article
- Fungicidal Activity of Volatile Organic Compounds Emitted byMolecules (Basel, Switzerland) · 2021Article
- Underground isoleucine biosynthesis pathways ineLife · 2020Article
- Brevibacterium from Austrian hard cheese harbor a putative histamine catabolism pathway and a plasmid for adaptation to the cheese environment.Scientific reports · 2019Article
- Mobilome ofFrontiers in microbiology · 2019Article
- Article
- Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation.BMC genomics · 2011Article
- Purification and characterization of a new L-methioninase from solid cultures of Aspergillus flavipes.Journal of microbiology (Seoul, Korea) · 2011Article
- Global regulation of the response to sulfur availability in the cheese-related bacterium Brevibacterium aurantiacum.Applied and environmental microbiology · 2011Article
- The arthrobacter arilaitensis Re117 genome sequence reveals its genetic adaptation to the surface of cheese.PloS one · 2010Article
- Heterologous production of methionine-gamma-lyase from Brevibacterium linens in Lactococcus lactis and formation of volatile sulfur compounds.Applied and environmental microbiology · 2009Article
- L-methioninase production by filamentous fungi: I-screening and optimization under submerged conditions.Current microbiology · 2009Article
- Comparative genomics of enzymes in flavor-forming pathways from amino acids in lactic acid bacteria.Applied and environmental microbiology · 2008Review
- Transcriptional analysis of L-methionine catabolism in the cheese-ripening yeast Yarrowia lipolytica in relation to volatile sulfur compound biosynthesis.Applied and environmental microbiology · 2008Article
- Cloning and characterization of two Lactobacillus casei genes encoding a cystathionine lyase.Applied and environmental microbiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enzymatic degradation of L-methionine and subsequent formation of volatile sulfur compounds (VSCs) is believed to be essential for flavor development in cheese. L-methionine-gamma-lyase (MGL) can convert L-methionine to methanethiol (MTL), alpha-ketobutyrate, and ammonia. The mgl gene encoding MGL was cloned from the type strain Brevibacterium linens ATCC 9175 known to produce copious amounts of MTL and related VSCs. The disruption of the mgl gene, achieved in strain ATCC 9175, resulted in a 62% decrease in thiol-producing activity and a 97% decrease in total VSC production in the knockout strain. Our work shows that L-methionine degradation via gamma-elimination is a key step in the formation of VSCs in B. linens.
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