ArticleApplied and environmental microbiology2004
Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
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- Molecular characterization of aureocin 4181: a natural N-formylated aureocin A70 variant with a broad spectrum of activity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Propionibacterium spp.-source of propionic acid, vitamin B12, and other metabolites important for the industry.Applied microbiology and biotechnology · 2018Review
- Dairy propionibacteria as probiotics: recent evidences.World journal of microbiology & biotechnology · 2016Review
- Heterologous expression of thuricin CD immunity genes in Listeria monocytogenes.Antimicrobial agents and chemotherapy · 2014Article
- Multifaceted attributes of dairy propionibacteria: a review.World journal of microbiology & biotechnology · 2012Review
- Transcription analysis of a lantibiotic gene cluster from Bifidobacterium longum DJO10A.Applied and environmental microbiology · 2011Article
- Genome mining for radical SAM protein determinants reveals multiple sactibiotic-like gene clusters.PloS one · 2011Article
- Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Construction of a reporter vector system for in vivo analysis of promoter activity in Propionibacterium freudenreichii.Applied and environmental microbiology · 2008Article
- Identification of the propionicin F bacteriocin immunity gene (pcfI) and development of a food-grade cloning system for Propionibacterium freudenreichii.Applied and environmental microbiology · 2007Article
- Heterologous production of antimicrobial peptides in Propionibacterium freudenreichii.Applied and environmental microbiology · 2005Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work describes the purification and characterization of propionicin F, the first bacteriocin isolated from Propionibacterium freudenreichii. The bacteriocin has a bactericidal activity and is only active against strains of P. freudenreichii. Propionicin F appears to be formed through a processing pathway new to bacteriocins. The mass of the purified bacteriocin was determined by mass spectrometry, and the N-terminal amino acid sequence was determined by Edman degradation. Sequencing of pcfA, the bacteriocin structural gene, revealed that propionicin F corresponds to a 43-amino-acid peptide in the central part of a 255-amino-acid open reading frame, suggesting that mature propionicin F is excised from the probacteriocin by N- and C-terminal proteolytic modifications. DNA sequencing and Northern blot hybridizations revealed that pcfA is cotranscribed with genes encoding a putative proline peptidase and a protein from the radical S-adenosylmethionine family. A gene encoding an ABC transporter was also identified in close proximity to the bacteriocin structural gene. The potential role of these genes in propionicin F maturation and secretion is discussed.
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