ArticleMolecular biology of the cell2005
Transcriptional networks and cellular senescence in human mammary fibroblasts.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
- Balancing senescence and apoptosis: therapeutic insights into aging and cancer.Molecular and cellular biochemistry · 2025Review
- Replicative senescence in amniotic fluid-derived mesenchymal stem cells and its impact on their immunomodulatory properties.Histochemistry and cell biology · 2025Article
- The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.Gastroenterology · 2023Article
- Common factors among three types of cells aged in mice.Biogerontology · 2023Article
- Molecular signatures distinguish senescent cells from inflammatory cells in aged mouse callus stromal cells.Frontiers in endocrinology · 2023Article
- Transcriptomic Analysis of Human PodocytesKidney international reports · 2023Article
- Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence.Scientific reports · 2021Article
- Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype.Frontiers in cell and developmental biology · 2021Review
- Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease.Journal of thoracic disease · 2019Article
- Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer.Oncotarget · 2016Review
- Article
- Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.PloS one · 2016Article
- Review
- Cellular senescence and aging: the role of B-MYB.Aging cell · 2014Review
- Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs.PloS one · 2014Article
- Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.Trends in cell biology · 2013Review
- Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival.Cell cycle (Georgetown, Tex.) · 2013Article
- Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.OncoTargets and therapy · 2013Review
- Stac3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle.The Journal of biological chemistry · 2012Article
- Senescence and NFκB: A trojan horse in tumors?Oncoimmunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Senescence, the molecular program that limits the finite proliferative potential of a cell, acts as an important barrier to protect the body from cancer. Techniques for measuring transcriptome changes and for modulating their expression suggest that it may be possible to dissect the transcriptional networks underlying complex cellular processes. HMF3A cells are conditionally immortalized human mammary fibroblasts that can be induced to undergo coordinated senescence. Here, we used these cells in conjunction with microarrays, RNA interference, and in silico promoter analysis to promote the dissection of the transcriptional networks responsible for regulating cellular senescence. We first identified changes in the transcriptome when HMF3A cells undergo senescence and then compared them with those observed upon replicative senescence in primary human mammary fibroblasts. In addition to DUSP1 and known p53 and E2F targets, a number of genes such as PHLDA1, NR4A3, and a novel splice variant of STAC were implicated in senescence. Their role in senescence was then analyzed by RNA silencing followed by microarray analysis. In silico promoter analysis of all differential genes predicted that nuclear factor-kappaB and C/EBP transcription factors are activated upon senescence, and we confirmed this by electrophoretic mobility shift assay. The results suggest a putative signaling network for cellular senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.