ArticleProceedings of the National Academy of Sciences of the United States of America1992
Mutual relationships between chromogranins A and B and gastrin in individual gastrin cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig.Histochemistry and cell biology · 2012Article
- Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes.World journal of gastroenterology · 2012Article
- Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains.The American journal of pathology · 2002Article
- Effects of Ostertagia ostertagi on gastrin gene expression and gastrin-related responses in the calf.The Journal of physiology · 1997Article
- Localization, expression, and characterization of guanylin in the rat adrenal medulla.Histochemistry and cell biology · 1996Article
- Analysis of the human guanylin gene and the processing and cellular localization of the peptide.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Immunocytochemical and ultrastructural heterogeneities of normal and glibenclamide stimulated pancreatic beta cells in the rat.Virchows Archiv : an international journal of pathology · 1994Article
- Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromogranins A and B (CgA and CgB, respectively), originally detected in the adrenal medulla, are present in various endocrine organs. Remarkably, their immunoreactivities vary among different endocrine cell types and also within a given endocrine cell population. With densitometric techniques at the cellular level, individual gastrin cells (n = 318) from guinea pig antral mucosa were studied to measure their content of immunoreactive CgA, CgB, and gastrin. The composition of these secretory proteins in individual gastrin cells varied considerably but with predictable components. Statistical evaluation of the data showed that immunoreactivities for gastrin and CgA correlated negatively in these cells; CgA and CgB immunoreactivities also correlated inversely. On the other hand, immunoreactivities for gastrin and CgB exhibited a high positive correlation. The mutual relationships between gastrin, CgA, and CgB suggest that under physiological conditions biosynthetic pathways of these secretory constituents are linked to each other in individual gastrin cells.
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