ArticleDigestive diseases and sciences2004
Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-kappaB.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Deciphering dynamic antibiotics-microbiome-metabolome interactions in preterm infants using systems biology.iScience · 2025Article
- A green strategy to produce potential substitute resource for bear bile using engineered Saccharomyces cerevisiae.Bioresources and bioprocessing · 2022Article
- Genistein Combined Polysaccharide (GCP) Can Inhibit Intracrine Androgen Synthesis in Prostate Cancer Cells.Biomedicines · 2020Article
- Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1Scientific reports · 2019Article
- Article
- Intestinal barrier integrity and function in infants with cholestasis.Intestinal research · 2017Article
- Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.World journal of gastroenterology · 2012Review
- Bile salts increase epithelial cell proliferation through HuR-induced c-Myc expression.The Journal of surgical research · 2012Article
- Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.Gastroenterology · 2010Article
- Dietary bile acid supplementation improves intestinal integrity and survival in a murine model.Journal of pediatric surgery · 2010Article
- Article
- Bile acids in regulation of intestinal physiology.Current gastroenterology reports · 2009Review
- Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.Experimental cell research · 2009Article
- Pathophysiology of increased intestinal permeability in obstructive jaundice.World journal of gastroenterology · 2007Review
- Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression.Annals of surgery · 2007Article
- Sucralfate prevents the delay of wound repair in intestinal epithelial cells by hydrogen peroxide through NF-kappaB pathway.Journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that the NF-kappaB pathway would be operative in the proliferative effect of bile salts on enterocytes. To determine this, we studied the effect of the bile salt taurodeoxycholate on cultured rat enterocyte proliferation and apoptosis and examined the role of NF-kappaB activation in these growth regulatory processes. Intestinal epithelial cells were grown for 6 days with or without taurodeoxycholate. Proliferation was measured. The cells were exposed to a known apoptotic stimulus, TNF-alpha and cyclohexamide. Apoptosis was quantified using cell number and the TUNEL stain. NF-kappaB activation was determined by an electrophoretic mobility shift assay. NF-kappaB activation was inhibited by an IkappaB superrepressor. Taurodeoxycholate stimulated cell proliferation (P < 0.01) and induced resistance to TNF-alpha induced apoptosis (P < 0.01). Taurodeoxycholate induced NF-kappaB activation. Inhibition of NF-kappaB prevented taurodeoxycholate-induced IEC-6 cell proliferation and rendered cells sensitive to TNF-alpha-induced apoptosis. Taurodeoxycholate stimulates intestinal epithelial cell proliferation and protects intestinal epithelial cells from TNF-alpha-induced apoptosis through NF-kappaB. These data support an important beneficial role of bile salts in regulation of mucosal growth and repair. Decreased enterocyte exposure to luminal bile salts, as occurs during starvation and parenteral nutrition, may have a detrimental effect on mucosal integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.