ArticleProceedings of the National Academy of Sciences of the United States of America1992
Heterogeneous expression of glucokinase among pancreatic beta cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 109 citations in OpenAlex.
- Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet CaeLife · 2025Article
- Glucokinase activity controls peripherally-located subpopulations of β-cells that lead islet CabioRxiv : the preprint server for biology · 2024Article
- Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells.Physiological research · 2024Review
- Readily releasable β cells with tight CaNature metabolism · 2024Article
- Differential CpG methylation atbioRxiv : the preprint server for biology · 2023Article
- A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes.Nature cell biology · 2023Article
- The physiological role of β-cell heterogeneity in pancreatic islet function.Nature reviews. Endocrinology · 2022Review
- Article
- Small subpopulations of β-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication.PLoS computational biology · 2021Article
- Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.American journal of physiology. Endocrinology and metabolism · 2021Review
- Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link?International journal of molecular sciences · 2021Review
- Human Islets Contain a Beta Cell Type That Expresses Proinsulin But Not the Enzyme That Converts the Precursor to Insulin.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [CaBiophysical journal · 2019Article
- The role of beta cell heterogeneity in islet function and insulin release.Journal of molecular endocrinology · 2018Review
- Article
- Heterogeneity of the Pancreatic Beta Cell.Frontiers in genetics · 2017Review
- A method for high-throughput functional imaging of single cells within heterogeneous cell preparations.Scientific reports · 2016Article
- Impact of islet architecture on β-cell heterogeneity, plasticity and function.Nature reviews. Endocrinology · 2016Review
- Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes.PloS one · 2014Article
- Glucose regulates rat beta cell number through age-dependent effects on beta cell survival and proliferation.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The cellular location of glucokinase (GK), a key component of the glucose-sensing mechanism of the pancreatic islet, was determined using immunocytochemical techniques. In rat islets, GK immunoreactivity was detected only in beta cells with no immunoreactivity detected in alpha, delta, or pancreatic polypeptide-containing (PP) cells. However, within various beta cells, GK immunoreactivity varied considerably. Most beta cells displayed relatively low levels of cytoplasmic immunoreactivity whereas other beta cells stained intensely for this enzyme. Colocalization studies of GK and GLUT2, the high Km glucose transporter of beta cells, confirmed that these proteins are located in different subcellular domains of beta cells. The lack of GK immunoreactivity in glucagon- and somatostatin-secreting cells in islets suggests that these cells are not directly responsive to glucose or utilize a fundamentally different mechanism for sensing glucose fluctuations. Moreover, the differential expression of GK among pancreatic beta cells suggests that glucose phosphorylation is the probable enzymatic control point for the functional diversity of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.