ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2004
Kinetics of organic transformations under mild aqueous conditions: implications for the origin of life and its metabolism.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Rapid hydrolysis rates of thio- and phosphate esters constrain the origin of metabolism to cool, acidic to neutral environments.iScience · 2024Article
- Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?Essays in biochemistry · 2024Review
- Non-enzymatic molecular damage as a prototypic driver of aging.The Journal of biological chemistry · 2017Review
- Pathway thermodynamics highlights kinetic obstacles in central metabolism.PLoS computational biology · 2014Article
- Rethinking glycolysis: on the biochemical logic of metabolic pathways.Nature chemical biology · 2012Review
- Molecular structure of humin and melanoidin via solid state NMR.The journal of physical chemistry. B · 2011Article
- Sugar-driven prebiotic synthesis of ammonia from nitrite.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2010Article
- Bioenergetics and life's origins.Cold Spring Harbor perspectives in biology · 2010Review
- Sugar-driven prebiotic synthesis of 3,5(6)-dimethylpyrazin-2-one: a possible nucleobase of a primitive replication process.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2008Article
- The sugar model: autocatalytic activity of the triose-ammonia reaction.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
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Abstract
The rates of thermal transformation of organic molecules containing carbon, hydrogen, and oxygen were systematically examined in order to identify the kinetic constraints that governed origin-of-life organic chemistry under mild aqueous conditions. Arrhenius plots of the kinetic data were used to estimate the reaction of half-lifes at 50 degrees C. This survey showed that hydrocarbons and organic substances containing a single oxygenated group were kinetically the most stable; whereas organic substances containing two oxygenated groups in which one group was an alpha- or beta-positioned carbonyl group were the most reactive. Compounds with an alpha- or beta-positioned carbonyl group (aldehyde or ketone) had rates of reaction that were up to 10(24)-times faster than rates of similar molecules lacking the carbonyl group. This survey of organic reactivity, together with estimates of the molecular containment properties of lipid vesicles and liquid spherules, indicates that an origins process in a small domain that used C,H,O-intermediates had to be catalytic and use the most reactive organic molecules to prevent escape of its reaction intermediates.
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