Evidence map›Paper›PMID 15573262›Full record

Trial reportWorld journal of surgery2004

Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer.

Claudio Zanon, Renzo Clara, Isabella Chiappino, Massimiliano Bortolini, Silvia Cornaglia, Paolo Simone, Francesco Bruno, Leonarda De Riu, Mario Airoldi, Fulvia Pedani

Abstract readClinical TrialClinical Trial, Phase II
PubMed Publisher
In one paragraph

Trial report in World journal of surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Surgical cytoreduction for recurrent epithelial ovarian cancer.The Cochrane database of systematic reviews · 2013
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
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  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. [Surgical treatment of peritoneal metastases from gynecological primary tumors].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Peritoneal carcinomatosis.World journal of gastroenterology · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Claudio ZanonDepartment of Oncology, S. Giovanni Battista Antica Sede Hospital, Via Cavour 31, 10100, Torino, Italy. zanoncl@tin.it
Renzo Clara
Isabella Chiappino
Massimiliano Bortolini
Silvia Cornaglia
Paolo Simone
Francesco Bruno
Leonarda De Riu
Mario Airoldi
Fulvia Pedani
Ospedale San Giovanni Antica Sede · ITAzienda Ospedaliero Universitaria San Giovanni Battista · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggressive surgical cytoreduction has been shown to have a positive impact on survival of patients with ovarian cancer. After first-line chemotherapy, 47% of patients relapse within 5 years, and median survival after second line chemotherapy is 10-15 months. Adding intraperitoneal chemohyperthermia (IPCH) to surgical cytoreduction could further control ceolomic spread of disease. The aim of this study was to determine morbidity and mortality, regional relapse-free survival and, preliminarily, overall survival after combining cytoreductive surgery with IPCH for the treatment of peritoneal carcinomatosis from ovarian epithelial cancer relapsed after prior chemotherapy. Thirty women affected with such a relapse were included. Patients underwent extensive cytoreductive surgery including tumor resections and peritonectomy, followed by intraoperative IPCH with cisplatin. Complete surgical cytoreduction down to nodules less than 2.5 mm (CC0-CC1) was obtained in 23 patients (77%). One patient died postoperatively from a pulmonary embolism. Major postoperative morbidity was 5/30 (16.7%). We registered one case of anastomotic leakage, a spontaneous ileum perforation, a postoperative cholecystitis, a hydrothorax, and one patient with bone marrow toxicity. Kaplan-Meier estimates of median locoregional relapse-free survival and median overall survival were 17.1 months and 28.1 months, respectively. Patients with CC0-CC1 had locoregional relapse-free and overall survival rates of 24.4 and 37.8 months, whereas the remainder had survival rates of 4.1 and 11.0 months. We concluded that cytoreductive surgery combined with IPCH is feasible with acceptable morbidity and mortality and seems to promise good results in selected patients affected with peritoneal carcinomatosis from ovarian cancer.

Indexed as

Hyperthermia, InducedAdultAgedCombined Modality TherapyFemaleHumansMiddle AgedNeoplasm Recurrence, LocalOvarian NeoplasmsPeritoneal NeoplasmsProspective StudiesSurvival Analysis

Identifiers

PMID15573262
OpenAlexW1982197711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.