ArticleParasitology research1992
Identification of diagnostic antigens from Trichinella spiralis.
Article in Parasitology research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Molecular mimicry between parasites and cancer: a novel approach for developing cancer vaccines and therapeutic antibodies.Cancer immunology, immunotherapy : CII · 2025Article
- Specific IgG4 response directed against the 45-kDa glycoprotein in trichinellosis: a re-evaluation of patients 15 years after infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2007Article
- Comparative analysis of Trichinella spiralis and Trichinella nativa proteins by two-dimensional gel electrophoresis.Parasitology research · 2006Article
- Evaluation of Trichinella spiralis larva group 1 antigens for serodiagnosis of human trichinellosis.Journal of clinical microbiology · 2004Article
- Imported human trichinellosis: sequential IgG4 antibody response to Trichinella spiralis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Article
- Development and evaluation of a Western blot kit for diagnosis of human trichinellosis.Clinical and diagnostic laboratory immunology · 2003Article
- Serological evaluation of thin-layer immunoassay-enzyme-linked immunosorbent assay for antibody detection in human trichinellosis.Clinical and diagnostic laboratory immunology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Western blotting technique was used to determine the antigens of Trichinella spiralis muscle larvae that were recognized by antibodies in sera from humans and pigs displaying T. spiralis infections. This resulted in the identification of several antigens that were recognized by all sera. Some of these antigens, notably those that were recognized during the early stage of infection, cross-reacted with antibodies to other parasites. This cross-reactivity was caused by the presence of phosphorylcholine on these antigens. A large portion of the antigens that were recognized by antibodies from infected humans and pigs were found to share a single Trichinella-specific determinant. The Trichinella-specific antigen population could be isolated from phosphorylcholine-containing antigens by a simple two-step affinity chromatography procedure using monoclonal antibodies to both determinants. The resulting preparation consisted primarily of a single antigen showing an apparent molecular weight of 45 kDa that corresponded to a major constituent of excretory-secretory (ES) products of muscle larvae. When tested in an enzyme-linked immunosorbent assay (ELISA), this antigen displayed diagnostic specificity that was comparable with the ES fraction and diagnostic sensitivity comparable with the crude muscle-larvae extract.
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