ArticleMolecular and cellular biology2004
PRAM-1 is required for optimal integrin-dependent neutrophil function.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection.PLoS pathogens · 2020Article
- RNA-Seq Analysis of Colorectal Tumor-Infiltrating Myeloid-Derived Suppressor Cell Subsets Revealed Gene Signatures of Poor Prognosis.Frontiers in oncology · 2020Article
- Early pathological characterization of murine dissecting abdominal aortic aneurysms.APL bioengineering · 2018Article
- PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.Frontiers in immunology · 2018Article
- Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.Frontiers in cellular and infection microbiology · 2017Review
- TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.Cell host & microbe · 2013Article
- The adapter protein ADAP is required for selected dendritic cell functions.Cell communication and signaling : CCS · 2012Article
- Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice.PLoS neglected tropical diseases · 2010Article
- Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects.Immunity & ageing : I & A · 2010Article
- Immunopathologies linked to integrin signalling.Seminars in immunopathology · 2010Review
- The ins and outs of leukocyte integrin signaling.Annual review of immunology · 2009Review
- Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice.The American journal of pathology · 2008Article
- Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.The Journal of clinical investigation · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
PML-retinoic acid receptor alpha (RARalpha) regulated adaptor molecule 1 (PRAM-1) is an intracellular adaptor molecule that is upregulated during the induced granulocytic differentiation of promyelocytic leukemic cells and during normal human myelopoiesis. This report describes the generation of PRAM-1-deficient mice and an analysis of the function of this adaptor in neutrophil differentiation and mature neutrophil function. We demonstrate here that neutrophil differentiation is not impaired in PRAM-1-deficient mice and that PRAM-1-deficient neutrophils function normally following engagement of Fcgamma receptors. In contrast, mature PRAM-1-null neutrophils exhibit significant defects in adhesion-dependent reactive oxygen intermediate production and degranulation. Surprisingly, other integrin-dependent responses, such as cell spreading and activation of several signaling pathways, are normal. Together, these findings demonstrate the uncoupling of key integrin-dependent responses in the absence of PRAM-1 and show this adaptor to be critical for select integrin functions in neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.