ArticleProceedings of the National Academy of Sciences of the United States of America2004
Genomic data support the hominoid slowdown and an Early Oligocene estimate for the hominoid-cercopithecoid divergence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Parting ways: Pan-Homo divergence revisited.Primates; journal of primatology · 2026Review
- Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes.Ecology and evolution · 2025Article
- Genome-wide analysis reveals the contributors to fast molecular evolution of the Chinese hook snout carp (Computational and structural biotechnology journal · 2024Article
- Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.ACR open rheumatology · 2022Article
- New Insights on the Evolution of the Sweet Taste Receptor of Primates Adapted to Harsh Environments.Animals : an open access journal from MDPI · 2020Article
- A comparison of humans and baboons suggests germline mutation rates do not track cell divisions.PLoS biology · 2020Article
- Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral Infections.Antibodies (Basel, Switzerland) · 2020Review
- The African ape-like foot ofeLife · 2019Article
- Primitive Old World monkey from the earliest Miocene of Kenya and the evolution of cercopithecoid bilophodonty.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Estimated Pacemaker for Great Apes Supports the Hominoid Slowdown Hypothesis.Evolutionary bioinformatics online · 2019Article
- Evolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation.Molecular neurobiology · 2018Article
- Precursors to language: Social cognition and pragmatic inference in primates.Psychonomic bulletin & review · 2017Article
- Human Germline Mutation and the Erratic Evolutionary Clock.PLoS biology · 2016Article
- Discovery of a new repeat family in the Callithrix jacchus genome.Genome research · 2016Article
- A mitogenomic phylogeny of living primates.PloS one · 2013Article
- Evidence for a convergent slowdown in primate molecular rates and its implications for the timing of early primate evolution.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A genome sequence resource for the aye-aye (Daubentonia madagascariensis), a nocturnal lemur from Madagascar.Genome biology and evolution · 2012Article
- Evolution of the couple cytochrome c and cytochrome c oxidase in primates.Advances in experimental medicine and biology · 2012Review
- Macroevolutionary dynamics and historical biogeography of primate diversification inferred from a species supermatrix.PloS one · 2012Article
- Lead levels in long-tailed macaque (Macaca fascicularis) hair from Singapore.Primates; journal of primatology · 2011Article
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3 authors.
Funding
Abstract
Several lines of indirect evidence suggest that hominoids (apes and humans) and cercopithecoids (Old World monkeys) diverged around 23-25 Mya. Importantly, although this range of dates has been used as both an initial assumption and as a confirmation of results in many molecular-clock analyses, it has not been critically assessed on its own merits. In this article we test the robusticity of the 23- to 25-Mya estimate with approximately 150,000 base pairs of orthologous DNA sequence data from two cercopithecoids and two hominoids by using quartet analysis. This method is an improvement over other estimates of the hominoid-cercopithecoid divergence because it incorporates two calibration points, one each within cercopithecoids and hominoids, and tests for a statistically appropriate model of molecular evolution. Most comparisons reject rate constancy in favor of a model incorporating two rates of evolution, supporting the "hominoid slowdown" hypothesis. By using this model of molecular evolution, the hominoid-cercopithecoid divergence is estimated to range from 29.2 to 34.5 Mya, significantly older than most previous analyses. Hominoid-cercopithecoid divergence dates of 23-25 Mya fall outside of the confidence intervals estimated, suggesting that as much as one-third of ape evolution has not been paleontologically sampled. Identifying stem cercopithecoids or hominoids from this period will be difficult because derived features that define crown catarrhines need not be present in early members of these lineages. More sites that sample primate habitats from the Oligocene of Africa are needed to better understand early ape and Old World monkey evolution.
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