Evidence map›Paper›PMID 15570201›Full record

Trial reportAnnals of surgery2004

The role of antibiotic prophylaxis in prevention of wound infection after Lichtenstein open mesh repair of primary inguinal hernia: a multicenter double-blind randomized controlled trial.

Theo J Aufenacker, Dirk van Geldere, Taco van Mesdag, Astrid N Bossers, Benno Dekker, Edo Scheijde, Roos van Nieuwenhuizen, Esther Hiemstra, John H Maduro, Jan-Willem Juttmann and 4 more

Registry-linked trialOpen access · greenAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01273818 (Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair), which is not on this map. Cited by 28 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 9 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01273818 phase4completednot on this mapstarted 2011, after this paper: background citation

Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study

TypeinterventionalSponsorDiskapi Teaching and Research HospitalRan2011 to 2013Enrolled276ConditionsInguinal HerniaArmsGentamicin and cefazolin, Cefazolin, Gentamicin
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 9 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Antibiotic prophylaxis for open mesh repair of groin hernia: systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2016
    Pooled it
  5. Antibiotic prophylaxis for hernia repair.The Cochrane database of systematic reviews · 2012
    Pooled it
  6. Pooled it
  7. Dramatic innovations in modern surgical subspecialties.Canadian journal of surgery. Journal canadien de chirurgie · 2010
    Pooled it
  8. European Hernia Society guidelines on the treatment of inguinal hernia in adult patients.Hernia : the journal of hernias and abdominal wall surgery · 2009
    Guideline
  9. Pooled it
  10. Prophylactic antibiotic use in elective inguinal hernioplasty in a trauma center.Hernia : the journal of hernias and abdominal wall surgery · 2012
    Trial
  11. Using antibiotic prophylaxis to reduce surgical site infection after shouldice repair.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Observational
  12. Article
  13. Review
  14. Article
  15. Giant Inguinal Herniae Managed by Primary Repair: A Case Series.Journal of clinical and diagnostic research : JCDR · 2017
    Article
  16. LateCase reports in surgery · 2017
    Article
  17. Article
  18. Observational
  19. Antibiotic prophylaxis in open inguinal hernia repair: a literature review and summary of current knowledge.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Theo J AufenackerDepartment of Surgery, Onze Lieve Vrouwe Gasthuis, Eerste Oosterparkstraat 279, 1091 HA Amsterdam, The Netherlands.
Dirk van Geldere
Taco van Mesdag
Astrid N Bossers
Benno Dekker
Edo Scheijde
Roos van Nieuwenhuizen
Esther Hiemstra
John H Maduro
Jan-Willem Juttmann
Diederik Hofstede
Cunera T M van Der Linden
Dirk J Gouma
Maarten P Simons
Westfriesgasthuis · NLOLVG · NLAcademic Medical Center · NLHewlett-Packard (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether the use of prophylactic antibiotics is effective in the prevention of postoperative wound infection after Lichtenstein open mesh inguinal hernia repair. SUMMARY BACKGROUND DATA: A recent Cochrane meta-analysis (2003) concluded that "antibiotic prophylaxis for elective inguinal hernia repair cannot be firmly recommended or discarded."

methodsPatients with a primary inguinal hernia scheduled for Lichtenstein repair were randomized to a preoperative single dose of 1.5 g intravenous cephalosporin or a placebo. Patients with recurrent hernias, immunosuppressive diseases, or allergies for the given antibiotic were excluded. Infection was defined using the Centers for Disease Control and Prevention criteria.

resultsWe included 1040 patients in the study between November 1998 and May 2003. According to the intention-to-treat principle, 1008 patients were analyzed. There were 8 infections (1.6%) in the antibiotic prophylaxis group and 9 (1.8%) in the placebo group (P = 0.82). There was 1 deep infection in the antibiotic prophylaxis group and 2 in the placebo group (P = 0.57). Statistical analysis showed an absolute risk reduction of 0.19% (95% confidence interval, -1.78%-1.40%) and a number needed to treat of 520 for the total number of infections. For deep infection, the absolute risk reduction is 0.20% (95% confidence interval, -0.87%-0.48%) with a number needed to treat of 508.

conclusionsA low percentage (1.7%) of wound infection after Lichtenstein open mesh inguinal (primary) hernia repair was found, and there was no difference between the antibiotic prophylaxis or placebo group. The results show that, in Lichtenstein inguinal primary hernia repair, antibiotic prophylaxis is not indicated in low-risk patients.

Indexed as

Antibiotic ProphylaxisSurgical MeshAnti-Bacterial AgentsCefuroximeDigestive System Surgical ProceduresDouble-Blind MethodFemaleHernia, InguinalHumansMaleMiddle AgedSurgical Wound InfectionAnti-Bacterial AgentsCefuroxime

Identifiers

PMID15570201
PMCPMC1356511
OpenAlexW2036461641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.