ArticleProceedings of the National Academy of Sciences of the United States of America2004
7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 90 citations in OpenAlex.
- Article
- Pineal Neurosteroids: Biosynthesis and Physiological Functions.Frontiers in endocrinology · 2020Review
- Brain-Derived Steroids, Behavior and Endocrine Conflicts Across Life History Stages in Birds: A Perspective.Frontiers in endocrinology · 2018Article
- 7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon.Scientific reports · 2015Article
- A new pathway mediating social effects on the endocrine system: female presence acting via norepinephrine release stimulates gonadotropin-inhibitory hormone in the paraventricular nucleus and suppresses luteinizing hormone in quail.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cytochromes p450 and skin cancer: role of local endocrine pathways.Anti-cancer agents in medicinal chemistry · 2014Review
- Biosynthesis and biological action of pineal allopregnanolone.Frontiers in cellular neuroscience · 2014Review
- Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration.Nature chemical biology · 2013Article
- Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes.Molecular endocrinology (Baltimore, Md.) · 2013Article
- New biosynthesis and biological actions of avian neurosteroids.Journal of experimental neuroscience · 2013Review
- A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras.Nature communications · 2013Article
- Possible role of pineal allopregnanolone in Purkinje cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides.Frontiers in endocrinology · 2012Article
- Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Measurement of steroid concentrations in brain tissue: methodological considerations.Frontiers in endocrinology · 2011Article
- Mode of action and functional significance of 7α-hydroxypregnenolone stimulating locomotor activity.Frontiers in endocrinology · 2011Article
- Neurosteroid biosynthesis and function in the brain of domestic birds.Frontiers in endocrinology · 2011Article
- Neurosteroid biosynthesis in the brain of amphibians.Frontiers in endocrinology · 2011Article
- Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.Nature medicine · 2010Article
- 7α-hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: identification, mode of action, and functional significance.Frontiers in endocrinology · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. In this study, we show that the newt brain actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid that stimulates locomotor activity. 7alpha-hydroxypregnenolone was identified as a most abundant amphibian neurosteroid in the newt brain by using biochemical techniques combined with HPLC, TLC, and GC-MS analyses. The production of 7alpha-hydroxypregnenolone in the diencephalon and rhombencephalon was higher than that in the telencephalon and peripheral steroidogenic glands. In addition, 7alpha-hydroxypregnenolone synthesis in the brain showed marked changes during the annual breeding cycle, with a maximal level in the spring breeding period when locomotor activity of the newt increases. Behavioral analysis of newts in the nonbreeding period demonstrated that administration of this previously undescribed amphibian neurosteroid acutely increased locomotor activity. In vitro analysis further revealed that 7alpha-hydroxypregnenolone treatment resulted in a dose-dependent increase in the release of dopamine from cultured brain tissue of nonbreeding newts. The effect of this neurosteroid on locomotion also was abolished by dopamine D(2)-like receptor antagonists. These results indicate that 7alpha-hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts through the dopaminergic system. This study demonstrates a physiological function of 7alpha-hydroxypregnenolone that has not been described previously in any vertebrate class. This study also provides findings on the regulatory mechanism of locomotor activity from a unique standpoint.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.