ArticleVirchows Archiv : an international journal of pathology2005
Osteopontin expression in ductal adenocarcinomas and undifferentiated carcinomas of the pancreas.
Article in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- SIBLINGs and SPARC families: their emerging roles in pancreatic cancer.World journal of gastroenterology · 2014Review
- Long-term survivor of a resected undifferentiated pancreatic carcinoma with osteoclast-like giant cells who underwent a second curative resection: A case report and review of the literature.Oncology letters · 2014Article
- Osteopontin splice variant as a potential marker for metastatic disease in pancreatic adenocarcinoma.Journal of gastroenterology and hepatology · 2014Article
- Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies.Frontiers of medicine · 2014Review
- Matricellular proteins osteopontin and osteonectin/SPARC in pancreatic carcinoma.Cancer biology & therapy · 2010Article
- Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection.Cancer science · 2010Article
- Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH.Journal of cancer research and clinical oncology · 2010Article
- Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells.International journal of cancer · 2009Article
- Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.Molecular cancer · 2007Article
- Osteopontin in pancreatic cancer: A systematic review.Medicine internationalArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopontin (OPN) is a non-collagenous extracellular matrix protein with pleiotropic functions, including mediation of cell adhesion and migration. Recently, high OPN serum levels were found in pancreatic ductal adenocarcinomas (PDACs) in which OPN mRNA was identified in macrophages. We investigated OPN expression at the protein level in 15 PDACs and 10 undifferentiated pancreatic carcinomas (UCs), 4 of them with osteoclast-like giant cells (OCGCs), to find out whether the degree of OPN expression is related to tumor infiltration by macrophages and the adhesive capacity of tumor cells. With regard to its potential adhesive function, we compared OPN expression in PDACs and UCs with that of E-cadherin and beta-catenin, two well-known adhesive molecules. OPN positivity was observed in two-thirds of PDACs (10/15) and in 7 UCs (7/10), including all 4 UCs with OCGCs. Apart from tumor cells, OPN was expressed in macrophages and OCGCs. When we assessed the relationship between the number of OPN-positive macrophages and tumor cells, we did not find any statistically significant correlation. There was also no correlation, either positive or negative, between OPN expression and E-cadherin and beta-catenin expression. The results demonstrated that, in PDACs and UCs, OPN is expressed in both tumor-associated macrophages and tumor cells. The biological significance of this dual expression pattern is not yet known. It is, however, unlikely that OPN has an adhesive function, since its expression pattern differs distinctly from that of E-cadherin or beta-catenin.
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