ArticleNature genetics2005
Natural variation in cardiac metabolism and gene expression in Fundulus heteroclitus.
Article in Nature genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 208 citations in OpenAlex.
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- Gene expression underlying parenting and being parented shows limited plasticity in response to different ambient temperatures.Molecular ecology · 2022Article
- Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology.BMC genomics · 2022Article
- Natural variation of the cardiac transcriptome in humans.RNA biology · 2021Article
- Interindividual plasticity in metabolic and thermal tolerance traits from populations subjected to recent anthropogenic heating.Royal Society open science · 2021Article
- Transcriptome profiling of Lymnaea stagnalis (Gastropoda) for ecoimmunological research.BMC genomics · 2021Article
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- Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions.PLoS genetics · 2017Article
- Long-term acclimation to reciprocal light conditions suggests depth-related selection in the marine foundation speciesEcology and evolution · 2017Article
- Acclimation and acute temperature effects on population differences in oxidative phosphorylation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Community Structure of Skin Microbiome of Gulf Killifish, Fundulus grandis, Is Driven by Seasonality and Not Exposure to Oiled Sediments in a Louisiana Salt Marsh.Microbial ecology · 2015Article
- The Elizabeth River Story: A Case Study in Evolutionary Toxicology.Journal of toxicology and environmental health. Part B, Critical reviews · 2015Review
- Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes.Molecular biology and evolution · 2014Article
- GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas.Blood cells, molecules & diseases · 2014Article
- Bulk segregant RNA-seq reveals expression and positional candidate genes and allele-specific expression for disease resistance against enteric septicemia of catfish.BMC genomics · 2013Article
- Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences.BMC genomics · 2013Article
- High natural gene expression variation in the reef-building coral Acropora millepora: potential for acclimative and adaptive plasticity.BMC genomics · 2013Article
- Transcription and redox enzyme activities: comparison of equilibrium and disequilibrium levels in the three-spined stickleback.Proceedings. Biological sciences · 2013Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Individual variation in gene expression is important for evolutionary adaptation and susceptibility to diseases and pathologies. In this study, we address the functional importance of this variation by comparing cardiac metabolism to patterns of mRNA expression using microarrays. There is extensive variation in both cardiac metabolism and the expression of metabolic genes among individuals of the teleost fish Fundulus heteroclitus from natural outbred populations raised in a common environment: metabolism differed among individuals by a factor of more than 2, and expression levels of 94% of genes were significantly different (P < 0.01) between individuals in a population. This unexpectedly high variation in metabolic gene expression explains much of the variation in metabolism, suggesting that it is biologically relevant. The patterns of gene expression that are most important in explaining cardiac metabolism differ between groups of individuals. Apparently, the variation in metabolism seems to be related to different patterns of gene expression in the different groups of individuals. The magnitude of differences in gene expression in these groups is not important; large changes in expression have no greater predictive value than small changes. These data suggest that variation in physiological performance is related to the subtle variation in gene expression and that this relationship differs among individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.