ArticleImmunogenetics2005
The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- TIM family gene polymorphism and susceptibility to rheumatoid arthritis: Systematic review and meta-analysis.PloS one · 2019Pooled it
- TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjects.Bioscience reports · 2018Pooled it
- Molecular Basis for the Differential Function of HAVCR1 Mucin Variants.Biomedicines · 2024Article
- Single Nucleotide Variants of the Human TIM-1 IgV Domain with Reduced Ability to Promote Viral Entry into Cells.Viruses · 2022Article
- Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases.Frontiers in immunology · 2021Review
- Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology.American journal of translational research · 2019Review
- Immune Regulation and Antitumor Effect of TIM-1.Journal of immunology research · 2016Review
- KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.The EMBO journal · 2015Article
- Expression and polymorphisms of T cell immunoglobulin domain and mucin domain protein-1 in thymoma with or without myasthenia gravis.Oncology letters · 2014Article
- The role of T cell immunoglobulin mucin domains 1 and 4 in a herpes simplex virus-induced Behçet's disease mouse model.Mediators of inflammation · 2013Article
- Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans.Gastroenterology · 2012Article
- TIM polymorphisms--genetics and function.Genes and immunity · 2011Review
- Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.The Journal of clinical investigation · 2011Article
- Identification of HAVCR1 gene haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases.Human genetics · 2010Article
- TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.Immunological reviews · 2010Review
- Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?Seminars in immunopathology · 2010Review
- Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.Experimental & molecular medicine · 2009Article
- The costimulatory role of TIM molecules.Immunological reviews · 2009Review
- TIM-1 and TIM-3 proteins in immune regulation.Cytokine · 2008Review
- Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.The Journal of clinical investigation · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been determined that the family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is expressed on T cells. A member of the TIM family, TIM-1, is considered to be a membrane protein associated with the development of Th2-biased immune responses and selectively expressed on Th2 cells. We previously showed that the exon 4 variations of Tim-1 are associated with susceptibility to allergic diseases, as well as autoimmune diseases such as rheumatoid arthritis (RA). In this study, we assessed the association between genotype and allele frequencies of the Tim-1 gene promoter region, in both RA patients and the controls without RA, using polymerase chain reaction-restriction fragment length polymorphism and single-base extension methods. We further investigated the relationships among the genotypes of each polymorphism and C-reactive protein or rheumatoid factor levels in RA patients. The genotype and allele frequencies of the -1637A>G polymorphism in RA patients are significantly different from those in the non-RA controls (P=0.0004 and P=0.001, respectively). Our results strongly suggest that polymorphism in the Tim-1 promoter region might be associated with susceptibility to RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.