Evidence map›Paper›PMID 15565277›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2005

Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy.

Mark G Kris, Paul J Hesketh, Jorn Herrstedt, Cynthia Rittenberg, Lawrence H Einhorn, Steven Grunberg, Jim Koeller, Ian Olver, Sussanne Borjeson, Enzo Ballatori

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Consensus recommendations for the prevention of vomiting and nausea following high-emetic-risk chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011
    Guideline
  3. SEOM clinical guidelines for the treatment of antiemetic prophylaxis in cancer patients receiving chemotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010
    Guideline
  4. Trial
  5. Results of a 7-day aprepitant schedule for the prevention of nausea and vomiting in 5-day cisplatin-based germ cell tumor chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Trial
  6. Trial
  7. Trial
  8. Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting.Journal of experimental & clinical cancer research : CR · 2009
    Trial
  9. Palonosetron (Aloxi) and dexamethasone for the prevention of acute and delayed nausea and vomiting in patients receiving multiple-day chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009
    Trial
  10. Trial
  11. Skipping day 2 antiemetic medications may improve chemotherapy induced delayed nausea and vomiting control: results of two pilot phase II trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2007
    Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. A qualitative study investigating chemotherapy-induced nausea as a symptom cluster.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Article
  18. Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Article
  19. Identification of a novel marker associated with risk for delayed chemotherapy-induced vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
    Article
  20. Review
4 · The record

Corrections and comments

  • Erratum issued
    Dosage error in article text
5 · Who and what money

Authors and funding

10 authors at 9 institutions in 6 countries.

Mark G KrisMemorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. krism@mskcc.org
Paul J Hesketh
Jorn Herrstedt
Cynthia Rittenberg
Lawrence H Einhorn
Steven Grunberg
Jim Koeller
Ian Olver
Sussanne Borjeson
Enzo Ballatori
Cancer Institute (WIA) · INCopenhagen University Hospital · DKLinköping University · SEMedica (Italy) · ITMemorial Sloan Kettering Cancer Center · USRoyal Adelaide Hospital · AUThe University of Texas at Austin · USTufts University · USUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper uses an evidence-based approach whenever possible to formulate recommendations, emphasizing the results of controlled trials concerning the best use of antiemetic agents. We address issues of dose, schedule, and route of administration of five selective 5-HT(3) antagonists. We conclude that for each of these five drugs, there is a plateau in therapeutic efficacy above which further dose escalation does not improve outcome. Furthermore, for all classes of antiemetic agents, a single dose is as effective as multiple doses or a continuous infusion. The oral route is as efficacious as the intravenous route of administration, even with chemotherapy of high emetic risk. Selective antagonists of the type 3 serotonin receptor (5-HT(3)) in combination with dexamethasone and aprepitant are the standard of care for the prevention of emesis following chemotherapy of high emetic risk.

Indexed as

AntiemeticsAntineoplastic AgentsClinical Trials as TopicConsensusDexamethasoneDrug Administration RoutesDrug Administration ScheduleDrug Therapy, CombinationEvidence-Based MedicineHumansNauseaNeurokinin-1 Receptor AntagonistsPractice Guidelines as TopicSerotonin 5-HT3 Receptor AntagonistsVomitingAntiemeticsAntineoplastic AgentsDexamethasoneNeurokinin-1 Receptor AntagonistsSerotonin 5-HT3 Receptor Antagonists

Identifiers

PMID15565277
OpenAlexW1984152751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.