ArticleJournal of virology2004
Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- The evolution of poxvirus vaccines.Viruses · 2015Review
- Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo.PloS one · 2013Article
- Lessons in nonhuman primate models for AIDS vaccine research: from minefields to milestones.Cold Spring Harbor perspectives in medicine · 2012Article
- Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques.Immunogenetics · 2011Article
- Co-expression of miRNA targeting the expression of PERK, but not PKR, enhances cellular immunity from an HIV-1 Env DNA vaccine.PloS one · 2011Article
- HIV vaccines: progress to date.Drugs · 2011Review
- Preexisting vaccinia virus immunity decreases SIV-specific cellular immunity but does not diminish humoral immunity and efficacy of a DNA/MVA vaccine.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor.Nucleic acids research · 2010Article
- Article
- Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.PLoS pathogens · 2009Article
- Peripheral NKT cells in simian immunodeficiency virus-infected macaques.Journal of virology · 2009Article
- Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge.Journal of virology · 2008Article
- CD4+ target cell availability determines the dynamics of immune escape and reversion in vivo.Journal of virology · 2008Article
- Vaccination and timing influence SIV immune escape viral dynamics in vivo.PLoS pathogens · 2008Article
- Utility of human immunodeficiency virus type 1 envelope as a T-cell immunogen.Journal of virology · 2007Article
- A heterologous DNA prime-Venezuelan equine encephalitis virus replicon particle boost dengue vaccine regimen affords complete protection from virus challenge in cynomolgus macaques.Journal of virology · 2007Article
- In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques.Journal of virology · 2007Article
- Vaccine-induced T cells control reversion of AIDS virus immune escape mutants.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations required, the effect of DNA vaccination alone, and the effect of cytokine (gamma interferon) coexpression by the fowlpox virus boost was also studied. A coordinated induction of high levels of broadly reactive CD4 and CD8 T-cell immune responses was induced by sequential DNA and fowlpox virus vaccination. The immunogenicity of regimens utilizing fowlpox virus coexpressing gamma interferon, a single DNA priming vaccination, or DNA vaccines alone was inferior. Significant control of a virulent SHIV challenge was observed despite a loss of SHIV-specific proliferating T cells. The outcome of challenge with virulent SHIV(mn229) correlated with vaccine immunogenicity except that DNA vaccination alone primed for protection almost as effectively as the DNA/fowlpox virus regimen despite negligible immunogenicity by standard assays. These studies suggest that priming of immunity with DNA and fowlpox virus vaccines could delay AIDS in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.